Sono-contrast spectroscopy for breast cancer detection
Sono-contrast spectroscopy for breast cancer detection
复制标题
用于乳腺癌检测的声对比光谱
DOI：
10.1117/12.779460
复制
发表时间：
2007
影响因子：
5.9
通讯作者：
L. Liao
中科院分区：
文献类型：
--
作者：
Yan Yu;L. Liao
在一项临床前研究中，我们证明了血液流动和组织氧合可以通过聚焦超声来操纵；这种操纵的效果是通过在氧合和脱氧血红蛋白显示不同消光特性的波长处的光学光谱来询问的。我们设计了一种基于这些非侵入性技术的临床乳腺扫描仪。除了聚焦的超声场与光学照明量和光谱采集点相交外，扫描头中还集成了一个诊断质量的乳房成像探头，以实现图像引导。对聚焦超声场特性、诊断成像能力和近红外光谱子系统的系统性能进行了实验确认，以证明已准备好进行临床研究，该研究涉及200名患者，这些患者计划接受超声引导下的活检，以排除乳腺癌。
In a preclinical study, we demonstrated that blood flow and tissue oxygenation could be manipulated by focused ultrasound; the effects of such manipulation were interrogated via optical spectroscopy at wavelengths where oxy- and deoxy-hemoglobin display different extinction properties. We have designed a clinical breast scanner based on these noninvasive techniques. In addition to the focused ultrasound field intersecting with the volume of optical illumination and points of spectral collection, a diagnostic quality breast imaging probe is incorporated into the scanhead to achieve image guidance. Experimental confirmation of the system performance of the focused ultrasound field properties, diagnostic imaging capabilities and NIR spectroscopy subsystem has been carried out to demonstrate readiness for a clinical study involving 200 patients who are scheduled to undergo ultrasound-guided biopsy to rule out breast cancers.
DOI：
--
发表时间：
1995-07
期刊：
The American journal of pathology
影响因子：
--
作者：
N. Weidner
通讯作者：
N. Weidner