Associations between particulate sulfate and organic carbon exposures and heart rate variability in patients with or at risk for cardiovascular diseases
Associations between particulate sulfate and organic carbon exposures and heart rate variability in patients with or at risk for cardiovascular diseases
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DOI：
10.1097/jom.0b013e318058205b
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Lee, Chung-Te
中科院分区：
文献类型：
--
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Lee, Chung-Te
目的：尚不清楚细颗粒中的特定成分是否与降低心率变异性（HRV）相关。方法：我们招募了46例患有或有心血管疾病的患者，可以通过心理心电图监测测量24小时HRV。固定位置空气监测站用于代表参与者对空气动力直径小于10 mu M（PM10）和2.5 mu M（PM2.5）的颗粒的暴露，以及硫酸盐，硝酸盐，有机碳（OC）的颗粒成分和元素碳和气态污染物。结果：我们发现，HRV还原与硫酸盐，OC和PM2.5有关，但与单污染物模型中的其他五种污染物无关。发现在三污染物模型中，硫酸盐与OC和PM2.5的HRV降低调节保持显着关联。结论：PM2.5中对硫酸盐和OC的暴露与患有或处于心血管疾病风险的患者的HRV降低有关。
Objective: It is still unknown whether specific components in fine particles are associated with heart rate variability (HRV) reduction. Methods: We recruited 46 patients with or at risk for cardiovascular diseases to measure 24-hour HRV by ambulatory electrocardiographic monitoring. Fixed-site air-monitoring stations were used to represent participants' exposures to particles with aerodynamic diameters less than 10 mu m (PM10) and 2.5 mu m (PM2.5), and particulate components of sulfate, nitrate, organic carbon (OC) and elemental carbon, and gaseous pollutants. Results: We found that HRV reduction was associated with sulfate, OC, and PM2.5 but not with the other five pollutants in single-pollutant models. Sulfate was found to remain in significant association with HRV reduction adjusting for OC and PM2.5 in three-pollutant models. Conclusions: Exposures to sulfate and OC in PM2.5 were associated with HRV reduction in patients with or at risk for cardiovascular diseases.