Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years
Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years
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DOI：
10.2302/kjm.2015-0010-oa
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发表时间：
2016-06-01
影响因子：
2
通讯作者：
Toyama, Yoshiaki
中科院分区：
文献类型：
--
作者：
Miyamoto, Takeshi;Katsuyama, Eri;Toyama, Yoshiaki
血清25-羟基维生素D(25(OH)D)水平低是髋部和脊柱骨折的危险因素。关于25(OH)D水平与骨折之间关系的研究主要涉及老年骨质疏松症患者或骨折患者；然而，年轻人的血清25(OH)D和甲状旁腺激素(PTH)状态仍很大程度上尚不清楚。我们评估了411名年龄在39-之间、没有接受骨质疏松症或其他骨病药物治疗的女性的血清25(OH)D和完整甲状旁腺素水平。血清25(OH)D水平与年龄呈正相关(P=0.019)，而正常甲状旁腺素水平与25(OH)D水平呈负相关(P<；0.001)。因此，低维生素D水平和高完整甲状旁腺素水平在年轻女性中比老年女性更常见。我们的数据显示，在年轻人群中，血清25(OH)D不足可能是一个比先前预期更严重的问题。由于血清25(OH)D不足是髋部和脊柱骨折的危险因素，未来骨折患者的数量可能会增加，这表明我们可能需要纠正血清维生素D/完整甲状旁腺素的状态，以防止未来的骨质疏松症。
Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39-64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.