Distinct roles of dopamine D3 receptors in modulating methamphetamine-induced behavioral sensitization and ultrastructural plasticity in the shell of the nucleus accumbens.
Distinct roles of dopamine D3 receptors in modulating methamphetamine-induced behavioral sensitization and ultrastructural plasticity in the shell of the nucleus accumbens.
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DOI：
10.1002/jnr.22821
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发表时间：
2012-04
影响因子：
4.2
通讯作者：
Chen, Teng
中科院分区：
文献类型：
--
作者：
Zhu, Jie;Chen, Yanjiong;Zhao, Na;Cao, Guofen;Dang, Yonghui;Han, Wei;Xu, Ming;Chen, Teng
关键词：
由于暴露于滥用药物而发生的行为和心理功能的持续变化被认为是由特定神经回路（如大脑的多巴胺（DA）系统）的结构可塑性介导的。树突状细胞形态的变化，在核延髓（NAc）伴随药物诱导的持久的行为和分子的变化，但在突触的超微结构的变化，反复暴露于药物还没有得到很好的研究。目前的研究探讨DA D3受体在调节自发活动诱导的急性和重复甲基苯丙胺（METH）管理和伴随的超微结构可塑性在壳的NAC小鼠的作用。我们发现，与野生型小鼠相比，D3受体突变（D3-/-）小鼠的急性运动反应减弱，并且对METH的行为致敏作用也减弱。在没有明显神经毒性作用的情况下，METH在野生型和D3−/−小鼠的NAc壳中诱导了类似的突触密度增加。这些结果表明，D3受体调节运动反应的急性和重复的METH治疗。与此相反，D3受体并不明显参与调节基线或甲基苯丙胺诱导的NAc壳超微结构的变化。
Persistent changes in behavior and psychological function that occur as a consequence of exposure to drugs of abuse are thought to be mediated by the structural plasticity of specific neural circuits such as the brain’s dopamine (DA) system. Changes in dendritic morphology in the nucleus accumbens (NAc) accompany druginduced enduring behavioral and molecular changes, yet ultrastructural changes in synapses following repeated exposure to drugs have not been well studied. The current study examines the role of DA D3 receptors in modulating locomotor activity induced by both acute and repeated methamphetamine (METH) administration and accompanying ultrastructural plasticity in the shell of NAc in mice. We found that D3 receptor mutant (D3−/−) mice exhibited attenuated acute locomotor responses as well as the development of behavioral sensitization to METH compared with wild-type mice. In the absence of obvious neurotoxic effects, METH induced similar increases in synaptic density in the shell of NAc in both wild-type and D3−/− mice. These results suggest that D3 receptors modulate locomotor responses to both acute and repeated METH treatment. In contrast, the D3 receptor is not obviously involved in modulating baseline or METH-induced ultrastructural changes in the NAc shell.
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影响因子：
4.7
作者：
Chen, Pei-Chun;Lao, Chu-Lan;Chen, Jin-Chung
通讯作者：
Chen, Jin-Chung
影响因子：
3.6
作者：
Pritchard, Laurel M.;Newman, Amy Hauck;Richtand, Neil M.
通讯作者：
Richtand, Neil M.
DOI：
10.1073/pnas.1834271100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Kolb, B;Gorny, G;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
10.6
作者：
Ferrario, CR;Gorny, G;Robinson, TE
通讯作者：
Robinson, TE