Polymorphisms of the prion gene promoter region that influence classical bovine spongiform encephalopathy susceptibility are not applicable to other transmissible spongiform encephalopathies in cattle
Polymorphisms of the prion gene promoter region that influence classical bovine spongiform encephalopathy susceptibility are not applicable to other transmissible spongiform encephalopathies in cattle
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DOI：
10.2527/jas.2007-0208
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发表时间：
2007-12-01
影响因子：
3.3
通讯作者：
Nicholson, E. M.
中科院分区：
文献类型：
--
作者：
Brunelle, B. W.;Hamir, A. N.;Nicholson, E. M.
据报道，牛朊病毒基因中的两个调节区多态性与对经典牛海绵状脑病（BSE）的抵抗力有关。然而，尚不清楚这种关联是否也适用于牛的其他传染性海绵状脑病 (TSE)。在本报告中，我们比较了受自然发生的非典型 BSE 影响的牛以及实验性接种瘙痒病、慢性消耗性疾病或传染性水貂脑病的牛中这 2 种多态性和耐药性之间的关系。我们的分析表明，基因型与对非典型 BSE 或实验接种的 TSE 的抗性之间没有关联。这表明启动子多态性相关性是经典 BSE 所特有的，并且非典型 BSE 和实验接种的 TSE 绕过了多态性的影响位点。这种遗传差异表明，非典型 BSE 在宿主中的进展情况与经典 BSE 不同。这些结果与非典型 BSE 自发起源于牛的观点一致。
Two regulatory region polymorphisms in the prion gene of cattle have been reported to have an association with resistance to classical bovine spongiform encephalopathy (BSE). However, it is not known if this association also applies to other transmissible spongiform encephalopathies (TSE) in cattle. In this report, we compare the relationship between these 2 polymorphisms and resistance in cattle affected with naturally occurring atypical BSE as well as in cattle experimentally inoculated with either scrapie, chronic wasting disease, or transmissible mink encephalopathy. Our analysis revealed no association between genotype and resistance to atypical BSE or experimentally inoculated TSE. This indicates the promoter polymorphism correlation is specific to classical BSE and that atypical BSE and experimentally inoculated TSE are bypassing the site of influence of the polymorphisms. This genetic discrepancy demonstrates that atypical BSE progresses differently in the host relative to classical BSE. These results are consistent with the notion that atypical BSE originates spontaneously in cattle.