Twenty-four-hour rhythm of prolactin depressive patients.
Twenty-four-hour rhythm of prolactin depressive patients.
复制标题
催乳素抑郁症患者的二十四小时节律。
作者：
U. Halbreich;L. Grunhaus;M. Ben
本文研究了7例抑郁症患者血清催乳素（PRL）水平的24小时节律。通过留置导管采血，用同源双抗体放射免疫法测定PRL水平。结果显示，与正常的24小时激素节律相比，抑郁症患者的催乳素分泌模式不同。结果显示，抑郁症患者的PRL水平在夜间（睡前数小时）显著升高，早晨略高，且从一次测定到连续测定的平均升高幅度较高。据推测，可能有一个昼夜节律性的情绪，特征的生命抑郁症，和不同的24小时节律性的PRL水平之间的连接。
Twenty-four-hour rhythms of serum prolactin (PRL) levels were studied in seven depressive patients. Blood was collected through an indwelling catheter and the PRL level was determined by homologous double antibody radioimmunoassay. Findings showed a different pattern of secretion of prolactin among depressives as compared to the normal 24-hour rhythm of the hormone. A statistically significant elevation of PRL levels during the evening, several hours before sleep, was found. Morning PRL levels were slightly higher and the average increase of PRL level from one determination to the consecutive one was higher among the depressives. It is assumed that there may be a connection between the diurnal rhythmicity of mood, characteristic of vital depression, and the different 24-hour rhythmicity of PRL level.