Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion
Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion
复制标题
DOI：
10.1016/j.ultrasmedbio.2006.08.016
复制
发表时间：
2007-03-01
影响因子：
2.9
通讯作者：
Okai, Takashi
中科院分区：
文献类型：
--
作者：
Ichihara, Mitsuyoshi;Sasaki, Kazuaki;Okai, Takashi
本研究利用超声图像引导高强度聚焦超声（HIFU）研究动脉血流阻断对组织坏死的诱导作用。我们构建了一个原型HIFU换能器与成像探头相结合，提供彩色多普勒成像和超声对比成像。HIFU光束瞄准体内肾动脉的一个分支。以4 kW/cm(2)的超声强度（每次超声2 ~ 10次，持续5 s）阻断8只家兔肾动脉分支。HIFU曝光成功后，彩色多普勒显像观察血流完全停止，成功率为100%（8/8）。此外，对比增强图像显示肾皮质缺乏灌注。死后组织学检查显示7例中有6例呈楔形梗死区，与超声图像缺乏造影剂相对应。这些结果表明，超声图像引导下的HIFU可以诱导动脉闭塞，使灌注组织发生梗死和坏死。（E-mail: m_itihara@hotmail.com） (c) 2007年世界医学和生物学超声联合会。
This study investigated the induction of tissue necrosis by arterial blood flow occlusion using ultrasound image-guided high-intensity focused ultrasound (HIFU). We constructed a prototype HIFU transducer in combination with an imaging probe that provided color Doppler imaging and ultrasound contrast imaging. The HIFU beam was aimed into a branch of the renal artery in vivo. The renal artery branches of eight rabbits were occluded by HIFU at an intensity of 4 kW/cm(2) (from 2 to 10 times of each sonication for 5 s). When the HIFU exposure was successful, complete cessation of blood flow was observed by color Doppler imaging with success rate of 100% (8/8). Furthermore, lack of perfusion was observed in the renal cortex with a contrast-enhanced image. Postmortem histologic evaluation showed a wedge-shaped area of infarction in six of seven cases, corresponding to the lack of the contrast medium in the ultrasound image. These results demonstrated that ultrasound image-guided HIFU can be used to induce arterial occlusion, thus producing infarction and necrosis of the perfused tissue. (E-mail: m_itihara@hotmail.com) (c) 2007 World Federation for Ultrasound in Medicine & Biology.