Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.
Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.
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作者：
Resztak JA;Farrell AK;Mair-Meijers H;Alazizi A;Wen X;Wildman DE;Zilioli S;Slatcher RB;Pique-Regi R;Luca F
社会互动和总体心理社会环境对健康有明显的影响，特别是对生活在城市贫困地区的人。在这里，我们调查了心理社会经验对底特律大都会哮喘儿童外周血免疫细胞基因表达的影响。使用RNA测序和新的机器学习方法，我们确定了19个变量的转录特征，包括心理社会因素，血细胞组成和哮喘症状。重要的是，我们发现了169个与哮喘或过敏性疾病相关的基因，这些基因受心理社会因素的调节，344个基因表达水平的显著基因-环境相互作用。这些结果表明，免疫基因表达介导的负面心理社会经验和哮喘风险之间的联系。
Social interactions and the overall psychosocial environment have a demonstrated impact on health, particularly for people living in disadvantaged urban areas. Here, we investigated the effect of psychosocial experiences on gene expression in peripheral blood immune cells of children with asthma in Metro Detroit. Using RNA-sequencing and a new machine learning approach, we identified transcriptional signatures of 19 variables including psychosocial factors, blood cell composition, and asthma symptoms. Importantly, we found 169 genes associated with asthma or allergic disease that are regulated by psychosocial factors and 344 significant gene-environment interactions for gene expression levels. These results demonstrate that immune gene expression mediates the link between negative psychosocial experiences and asthma risk.