Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.
Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.
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DOI：
10.1016/s0065-230x(09)05007-6
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发表时间：
2009
影响因子：
--
通讯作者：
Thomas-Tikhonenko, Andrei
中科院分区：
文献类型：
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作者：
Sala, Arturo;Bettuzzi, Saverio;Pucci, Sabina;Chayka, Olesya;Dews, Michael;Thomas-Tikhonenko, Andrei
在癌症遗传学中，聚集素(CLU)的功能在其他领域中争议最大。经过20多年的研究，CLU在人类癌症中的作用仍然存在不确定性。一些研究人员认为CLU是癌基因，另一些人认为CLU是肿瘤发生的抑制因子。然而，由于最近几个实验室的努力，CLU在重要的细胞过程中的作用开始显现，如增殖、凋亡、分化和转化。“神秘的”CLU正变得不那么神秘。在本章中，我们将回顾研究团队的工作，他们对了解CLU是如何被致癌信号调控感兴趣的。我们将讨论癌基因和表观遗传因子如何以及在什么情况下改变CLU的表达，这对哺乳动物的肿瘤发生具有重要的影响。
In no other field has the function of clusterin (CLU) been more controversial than in cancer genetics. After more than 20 years of research, there is still uncertainty with regard to the role of CLU in human cancers. Some investigators believe CLU to be an oncogene, others - an inhibitor of tumorigenesis. However, owing to the recent efforts of several laboratories, the role of CLU in important cellular processes like proliferation, apoptosis, differentiation and transformation is beginning to emerge. The “enigmatic” CLU is becoming less so. In this chapter we will review the work of research teams interested in understanding how CLU is regulated by oncogenic signalling. We will discuss how and under what circumstances oncogenes and epigenetic factors modify CLU expression, with important consequences for mammalian tumorigenesis.