Neighborhood Racial and Economic Privilege and Timing of Pubertal Onset in Girls.
Neighborhood Racial and Economic Privilege and Timing of Pubertal Onset in Girls.
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DOI：
10.1016/j.jadohealth.2022.10.013
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发表时间：
2023-03
影响因子：
7.6
通讯作者：
Kubo, Ai
中科院分区：
文献类型：
--
作者：
Acker, Julia;Mujahid, Mahasin;Aghaee, Sara;Gomez, Scarlett;Shariff-Marco, Salma;Chu, Brandon;Deardorff, Julianna;Kubo, Ai
关键词：
青春期提前与生命过程中的不良健康结果有关，黑人和西班牙裔女孩比其他种族/民族背景的女孩更早经历青春期。邻里的种族和经济特权可能会通过赋予不同的机制（例如，压力、肥胖、内分泌干扰物）导致青春期提前。我们在一个大型多种族队列中研究了邻里特权（用极端集中指数（ICE）测量）与阴毛开始（阴毛初长）和乳房发育开始（乳房初长）年龄之间的关联。对2005年至2011年在北方加州医疗机构出生的46,299名女孩进行了随访，直到2021年。青春期发育由儿科医生使用性成熟评定量表进行常规评估。ICE种族/民族、收入和收入+种族/民族的五分位数是使用美国社区调查2010年5年估计值计算的，并与出生时的人口普查区相关联。我们拟合多级Weibull回归模型，以适应所有分析的左，右和区间删失。ICE测量与青春期开始单调相关，ICE-人种/种族观察到的相关性最强。调整母亲教育，分娩年龄和产次，最少与最特权ICE种族/民族五分之一的女孩在早期阴毛初长（风险比：1.30，95%置信区间：1.21，1.38）和乳房初长（风险比：1.45，95%置信区间：1.36，1.54）的风险增加。在调整女孩的种族/民族和儿童体重指数后，这些关联仍然显着。此外，ICE的调整部分减弱了黑人-白人和西班牙裔-白人在青春期开始时的差异。邻里特权可能有助于青春期的时间和相关的差异。
Early puberty is associated with adverse health outcomes over the life course, and Black and Hispanic girls experience puberty earlier than girls of other racial/ethnic backgrounds. Neighborhood racial and economic privilege may contribute to these disparities by conferring differential exposure to mechanisms (e.g., stress, obesity, endocrine disruptors) underlying early puberty. We examined associations between neighborhood privilege, measured by the Index of Concentration at the Extremes (ICE), and age at pubic hair onset (pubarche) and breast development onset (thelarche) in a large multiethnic cohort. A cohort of 46,299 girls born 2005–2011 at Kaiser Permanente Northern California medical facilities were followed until 2021. Pubertal development was assessed routinely by pediatricians using the Sexual Maturity Rating scale. ICE quintiles for race/ethnicity, income, and income + race/ethnicity were calculated using American Community Survey 2010 5-year estimates and linked to census tract at birth. We fit multilevel Weibull regression models accommodating left, right, and interval censoring for all analyses. ICE measures were monotonically associated with pubertal onset, with the strongest associations observed for ICE–race/ethnicity. Adjusting for maternal education, age at delivery, and parity, girls from the least versus most privileged ICE–race/ethnicity quintiles were at increased risk for earlier pubarche (hazard ratio: 1.30, 95% confidence interval: 1.21, 1.38) and thelarche (hazard ratio: 1.45, 95% confidence interval: 1.36, 1.54). These associations remained significant after adjusting for girls’ race/ethnicity and childhood body mass index. Additionally, adjustment for ICE partially attenuated Black–White and Hispanic–White disparities in pubertal onset. Neighborhood privilege may contribute to pubertal timing and related disparities.
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影响因子：
5.4
作者：
Ley SH;Li Y;Tobias DK;Manson JE;Rosner B;Hu FB;Rexrode KM
通讯作者：
Rexrode KM
影响因子：
2.6
作者：
Glass, Delaney J.;Geerkens, Joy T.;Martin, Melanie A.
通讯作者：
Martin, Melanie A.
影响因子：
6.3
作者：
Krieger, N
通讯作者：
Krieger, N
影响因子：
2.4
作者：
Aghaee S;Deardorff J;Greenspan LC;Quesenberry CP Jr;Kushi LH;Kubo A
通讯作者：
Kubo A
影响因子：
11.2
作者：
Fuhrman BJ;Moore SC;Byrne C;Makhoul I;Kitahara CM;Berrington de González A;Linet MS;Weiderpass E;Adami HO;Freedman ND;Liao LM;Matthews CE;Stolzenberg-Solomon RZ;Gaudet MM;Patel AV;Lee IM;Buring JE;Wolk A;Larsson SC;Prizment AE;Robien K;Spriggs M;Check DP;Murphy N;Gunter MJ;Van Dusen HL Jr;Ziegler RG;Hoover RN
通讯作者：
Hoover RN