The Frontal Area with Higher Frequency Response Is the Principal Feature of Laser-Evoked Potentials in Rats with Chronic Inflammatory Pain: A Parallel Factor Analysis Study.
The Frontal Area with Higher Frequency Response Is the Principal Feature of Laser-Evoked Potentials in Rats with Chronic Inflammatory Pain: A Parallel Factor Analysis Study.
复制标题
具有较高频率响应的额区是慢性炎症疼痛大鼠激光诱发电位的主要特征：平行因子分析研究
DOI：
10.3389/fneur.2017.00155
复制
发表时间：
2017
影响因子：
3.4
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Wang J;Wang J;Wan Y;Li X
慢性疼痛是疼痛的病理发展过程。在临床上，需要一个客观的指标来诊断和更好地控制慢性疼痛。慢性疼痛的异常神经反应可通过多个事件相关电位（ERP）分别在时间、频率和位置域上反映出来。然而，ERPs的多次改变不适用于临床。因此，在慢性疼痛的发展过程中，从ERP的这三个领域提取的最有信息量的变化的主要特征是必要的。采用平行因子分析方法同时提取慢性炎性痛大鼠激光诱发电位（LEP）的时-频-通道特征。结果表明，慢性炎症痛大鼠通道域LEP的主要特征位于额叶脑区，而对照大鼠则位于顶叶脑区。在频域上，慢性炎性痛大鼠LEP的主频显著高于对照组。这些结果表明，额区对伤害性信息的高频反应是慢性疼痛状态的主要特征。我们的研究不仅提供了LEP的一个主要特征，而且为慢性疼痛的治疗提供了一个有希望的策略，具有潜在的临床应用价值。
Chronic pain is a pathological developing course of pain. In clinic, an objective indicator is needed for diagnosing and better controlling chronic pain. The abnormal neural responses in chronic pain are reflected by multiple event-related potentials (ERPs) in time, frequency, and location domain, respectively. However, multiple changes in ERPs are not applicable in clinic. So, the principal feature covered the most informative changes extracted from these three domains of ERP during the development of chronic pain is needed. In the present study, a parallel factor analysis method was employed to extract time–frequency–channel features of laser-evoked potential (LEP) simultaneously from rats with chronic inflammatory pain. Results showed that the main feature of LEP in channel domain locates in the frontal brain region in rats with chronic inflammatory pain while in the parietal brain region in control rats. In the frequency domain, the main frequency of LEP was significantly higher in chronic inflammatory pain rats than that in control rats. These findings indicate that the frontal region with higher frequency response to nociceptive information is the principal feature in the chronic pain state. Our study provided not only a principal feature of LEP but also a promising strategy for chronic pain, which is potential for clinic application.