Late-life Depression: Evidence-based Treatment and Promising New Directions for Research and Clinical Practice
Late-life Depression: Evidence-based Treatment and Promising New Directions for Research and Clinical Practice
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DOI：
10.1016/j.psc.2011.02.005
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发表时间：
2011-06-01
影响因子：
1.7
通讯作者：
Reynolds, Charles F., III
中科院分区：
文献类型：
--
作者：
Andreescu, Carmen;Reynolds, Charles F., III
随着人口老龄化，连续的老年人队列将经历抑郁障碍。晚年抑郁(LLD)增加了自杀、医疗合并症、残疾和家庭护理负担的风险。尽管药物治疗和电休克治疗的反应率和缓解率与中年抑郁症患者相当，但复发率更高，这突显了实现和保持健康的挑战。本文回顾了LLD治疗方案的证据基础，并对难以治疗的LLD变种(如精神病性抑郁症、血管性抑郁症)的治疗方案进行了分析。基于反应的预测因素和有希望的新的治疗选择，治疗算法也被综述。
As the population ages, successive cohorts of older adults will experience depressive disorders. Late-life depression (LLD) carries additional risk for suicide, medical comorbidity, disability, and family caregiving burden. Although response and remission rates to pharmacotherapy and electroconvulsive therapy are comparable with those in midlife depression, relapse rates are higher, underscoring the challenge to achieve and maintain wellness. This article reviews the evidence base for LLD treatment options and provides an analysis of treatment options for difficult-to-treat LLD variants (eg, psychotic depression, vascular depression). Treatment algorithms are also reviewed based on predictors of response and promising novel treatment options.