Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats
Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats
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DOI：
10.1046/j.1439-0264.2002.00359.x
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发表时间：
2002-04-01
影响因子：
0.9
通讯作者：
Al-Bader, A
中科院分区：
文献类型：
--
作者：
Abul, H;Mathew, TC;Al-Bader, A
测定硫代乙酰胺诱导的肝硬化大鼠的血液和肝组织中超氧化物歧化酶和谷胱甘肽过氧化物酶的水平，并与年龄匹配的对照动物的水平进行比较。还测定了这些动物的血浆尿酸水平。与对照相比，所有检查的抗氧化剂的水平普遍下降。除血液中超氧化物歧化酶水平外，所有研究的抗氧化剂水平的下降具有统计学意义。抗氧化剂水平的降低可能表明自由基水平增加，从而导致肝硬化大鼠细胞损伤增加。抗氧化剂水平的变化与我们之前研究中观察到的微量元素水平的变化直接相关。这些研究表明，单独使用抗氧化剂或与微量元素结合使用可能对治疗肝硬化具有有益作用。
Levels of superoxide dismutase and glutathione peroxidase were determined in blood and hepatic tissues of thioacetamide-induced cirrhotic rats and compared to levels in age-matched control animals. The plasma level of uric acid was also determined in these animals. A general decrease was noticed in the level of all the antioxidants examined as compared to the control. This decrease was statistically significant in the level of all the antioxidants studied, except for the level of superoxide dismutase in blood. A decrease in the antioxidant level may indicate an increase in free radical level and thereby an increase in cellular damage in cirrhotic rats. The changes in the level of antioxidants showed a direct correlation with the changes in the level of trace elements observed in our previous studies. These studies suggest that antioxidants alone or in combination with trace elements may have beneficial effects in treating liver cirrhosis.