The role of event-related potentials in cognitive decline in Alzheimer's disease
The role of event-related potentials in cognitive decline in Alzheimer's disease
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DOI：
10.1016/j.clinph.2009.11.001
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发表时间：
2010-02-01
影响因子：
4.7
通讯作者：
Liu, Ching-Kuan
中科院分区：
文献类型：
--
作者：
Lai, Chiou-Lian;Lin, Ruey-Tay;Liu, Ching-Kuan
目的：随着阿尔茨海默病（AD）的疾病改善治疗变得可用，疾病进展的早期诊断和监测在临床实践中变得至关重要。本研究旨在探讨事件相关电位（ERP）在认知功能减退中的作用及其在AD中的意义。方法：采用认知能力筛查工具（CASI）和ERP，对AD疑似患者、轻度认知功能障碍（MCI）患者和正常对照者进行研究。AD和MCI患者的认知功能明显下降，P300潜伏期延长。在可能的AD和MCI患者中，P300潜伏期比基线值显著延长，尽管他们的CASI评分未显示统计学显著下降。而N100、P200和N200分量在基线和随访评估中均未达到统计学差异，并且在随访中未显示出显著变化。结论：神经心理学测试和P300测量的组合被证明在提高AD患者早期认知下降或疾病进展的可靠性和增加敏感性方面是有用的。P300潜伏期可能比神经心理学测试更敏感地反映AD患者纵向随访中的认知功能下降。(C)2009年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objectives: Early diagnosis and monitoring of disease progression have become vital in clinical practice as disease modifying treatments for Alzheimer's disease (AD) become available. This one-year prospective study aimed to clarify the usefulness of event-related potentials (ERPs) in cognitive decline and elucidate their cognitive significance in AD.Methods: Using the Cognitive Abilities Screening Instrument (CASI) and ERPs, probable AD patients, mild cognitive impairment (MCI) patients, and normal controls were recruited.Results: The AD and MCI patients had significantly decreased cognitive function and manifested a delay of P300 latency. The P300 latencies demonstrated significantly more prolongation than their baseline values in probable AD and MCI patients, although their CASI scores showed no statistically significant decline. Whereas N100, P200, and N200 components did not reach statistical differences between groups either in the baseline or follow-up assessments and did not show significant change on follow-up.Conclusion: The combination of neuropsychological tests and P300 measurements proved useful in improving reliability and increasing sensitivity to early cognitive decline or disease progression in AD patients.Significance: The P300 latency may reflect cognitive decline more sensitively than neuropsychological tests in the longitudinal follow-up of AD patients. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.