Epidemic Profile of Maternal Syphilis in China in 2013.
Epidemic Profile of Maternal Syphilis in China in 2013.
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DOI：
10.1155/2016/9194805
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发表时间：
2016
影响因子：
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通讯作者：
Wang A
中科院分区：
文献类型：
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作者：
Dou L;Wang X;Wang F;Wang Q;Qiao Y;Su M;Jin X;Qiu J;Song L;Wang A
Objective.本研究的目的是了解我国孕妇梅毒感染的流行病学特征和不良妊娠结局。方法.数据来源于中国预防母婴传播管理信息系统。在该系统中登记并于2013年分娩的妇女被纳入分析。结果2013年全国共分娩梅毒感染孕妇15884例。79.1%的受感染妇女在妊娠37周或之前接受了产前护理;然而，55.4%的受感染妇女没有接受治疗或在妊娠37周后开始治疗。14.0%的妇女遭受严重的不良妊娠结局，包括死产/新生儿死亡、早产/低出生体重或新生儿先天性梅毒。高母体滴度（≥1：64）和晚期治疗（>37孕周）/未治疗与先天性梅毒风险增加显著相关，调整后OR分别为1.88（95%CI 1.27 ~ 2.80）和3.70（95%CI 2.36 ~ 5.80）。结论在中国，梅毒影响着大量的孕妇。很大一部分妇女在怀孕早期没有得到检查和治疗。受感染妇女的不良妊娠后果负担很高。仍然需要加强综合干预措施，以提高孕产妇梅毒筛查和治疗的接受率。
Objective. The aim of this study was to investigate the epidemiological characteristics and adverse pregnancy outcomes of pregnant women with syphilis infection in China. Methods. Data were from China's Information System of Prevention of Mother-to-Child Transmission of Syphilis Management. Women who were registered in the system and delivered in 2013 were included in the analysis. Results. A total of 15884 pregnant women with syphilis infection delivered in China in 2013. 79.1% of infected women attended antenatal care at or before 37 gestational weeks; however, 55.4% received no treatment or initiated the treatment after 37 gestational weeks. 14.0% of women suffered serious adverse pregnancy outcomes including stillbirth/neonatal death, preterm delivery/low birth weight, or congenital syphilis in newborns. High maternal titer (≥1 : 64) and late treatment (>37 gestational weeks)/nontreatment were significantly associated with increased risk of congenital syphilis and the adjusted ORs were 1.88 (95% CI 1.27 to 2.80) and 3.70 (95% CI 2.36 to 5.80), respectively. Conclusion. Syphilis affects a great number of pregnant women in China. Large proportions of women are not detected and treated at an early pregnancy stage. Burden of adverse pregnancy outcomes is high among infected women. Comprehensive interventions still need to be strengthened to improve uptake of screening and treatment for maternal syphilis.