Intracellular cyclic AMP concentration responds specifically to growth regulation by serum.
Intracellular cyclic AMP concentration responds specifically to growth regulation by serum.
复制标题
细胞内环磷酸腺苷浓度对血清的生长调节有特异性反应。
DOI：
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发表时间：
1974
影响因子：
11.1
通讯作者：
R. Pollack
中科院分区：
文献类型：
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作者：
J. Oey;A. Vogel;R. Pollack
当细胞被剥夺血清时，细胞内cAMP浓度增加。对小鼠成纤维细胞系3T3（3T3的SV40转化亚系）和来自该克隆的六种不同回复突变体系的研究表明，只有当血清浓度降低至低于给定系生长所需的最低浓度时，环AMP才会显著增加。相反，密度依赖性生长抑制并不伴随着环AMP浓度的增加，在任何线路。
Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.