Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
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DOI：
10.1073/pnas.0705036104
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发表时间：
2007-11-27
影响因子：
11.1
通讯作者：
de Leon, Mony J.
中科院分区：
文献类型：
--
作者：
Mosconi, Lisa;Brys, Miroslaw;de Leon, Mony J.
父母患有晚发性阿尔茨海默病（AD）是认知正常受试者发生AD的危险因素。我们研究了父母有阿尔茨海默病家族史的认知正常受试者与没有家族史的受试者相比，是否表现出与阿尔茨海默病一致的脑葡萄糖代谢率（CMRglc）降低，以及父母性别是否有影响。49名50- 80岁的正常受试者接受了临床、神经心理学和2-[F-18]氟-2-脱氧-d -葡萄糖正电子发射断层扫描检查，其中16名有母体（FHm） AD家族史，8名有父亲（FHp） AD家族史，25名无家族病史（FH-） AD家族史。FH组在人口学和神经心理学测量方面具有可比性。与FH-组和FHp组相比，FHm受试者与临床影响的AD患者在相同区域显示CMRglc降低，涉及后扣带皮层/楔前叶、顶叶和额叶皮质以及内侧颞叶（P < 0.05，经多次比较校正）。在考虑了年龄、性别、教育程度、载脂蛋白E基因型和主观记忆抱怨等AD可能的风险因素后，这些影响仍然显著。FHp和FH-组间CMRglc无差异。本研究显示认知正常个体中AD易感脑区CMRglc降低与母体AD家族史之间的关系。
Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[F-18]fluoro-2-deoxy-D-glucose-positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH-). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH- and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (P < 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH- subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.