NMR COMPARTMENTALIZATION OF FREE-WATER IN THE PERFUSED RAT-HEART
NMR COMPARTMENTALIZATION OF FREE-WATER IN THE PERFUSED RAT-HEART
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DOI：
10.1002/mrm.1910020302
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
CHAMBRON, J
中科院分区：
文献类型：
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作者：
MAUSS, Y;GRUCKER, D;CHAMBRON, J
在两种实验条件下测量了大鼠心脏的自旋-晶格弛豫时间（T1）和自旋-自旋弛豫时间（T2）。另一方面，T2有两个分量的衰变：一个短的T2和一个长的T21。这些事实已经根据交叉弛豫和组织的双室化进行了讨论，假设自旋-自旋弛豫的慢交换模型和自旋-晶格弛豫的快交换模型。增加灌注液的渗透压降低了T2 s室的绝对密度质子，反映了其水含量的损失。顺磁离子锰使T_1和长组分T_21的值减小，而不影响其短组分。因此，短组分可归属于细胞内自由水，长组分归属于细胞外自由水。细胞外T2（459 ms）比细胞内T2（45 ms）高约10倍。对于“纯T2”图像，这种差异可能有助于增强器官与周围液体之间或具有不同水区室的器官之间的对比度。
Spin‐lattice (T1) and spin‐spin (T2) relaxation times have been measured on perfused rat hearts under two experimental conditions.T1exhibits a monoexponential decay. On the other handT2has a decay with two components: a short oneT2sand a long oneT21. These facts have been discussed according to cross‐relaxation and a bicompartmen‐talization of tissue assuming a slow exchange model for spin‐spin relaxation and a fast exchange model for spin‐lattice relaxation. Increasing the osmotic pressure of the perfusion solution decreased the absolute density proton of theT2scompartment reflecting the loss of its water content. The paramagnetic ion manganese diminishes the values ofT1and those of the long componentT21without affceting its short component. Therefore the short component could be assigned to intracellular and the long component to extracellular free water. The extracellularT2(459 ms) is approximatively 10‐fold higher than the intracellularT2(45 ms) With images of “pureT2” such a difference could be useful to enhance the contrast between organs and the surrounding liquid or between organs with different water compartmentalization.