5-Aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett's oesophagus: a randomised trial
5-Aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett's oesophagus: a randomised trial
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DOI：
10.1136/gut.2003.028860
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发表时间：
2004-06-01
期刊：
影响因子：
24.5
通讯作者：
Kuipers, EJ
中科院分区：
文献类型：
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作者：
Hage, M;Siersema, PD;Kuipers, EJ
背景：Barrett‘s食道(BO)的消融方法有光化学和热学两种方法。本研究的目的是比较5-氨基乙酰丙酸诱导的光动力疗法(ALA-PDT)和氩离子凝固术(APC)在完全逆转BOB方面的作用。方法：BO患者(32例无不典型增生和8例轻度不典型增生)随机分为三组：(A)ALA-PDT单次剂量100J/cm(2)，4小时后(PDT100；n=13)；(B)ALA-PDT(分次剂量分别为20和100 J/cm(2)，1小时和4小时(PDT20+100；n=13)；或(C)功率设置为65W的APC，分两次进行(APC；n=14)。结果：6周时，PDT100组BO平均减少51%(20-100%)，PDT20+100组减少86%(0-100%)，APC组减少93%(40-100%，P<0.05)。
Background: Photochemical and thermal methods are used for ablating Barrett's oesophagus (BO). The aim of this study was to compare 5-aminolevulinic acid induced photodynamic therapy (ALA-PDT) with argon plasma coagulation (APC) with respect to complete reversal of BO.Methods: Patients with BO (32 no dysplasia and eight low grade dysplasia) were randomised to one of three treatments: (a) ALA-PDT as a single dose of 100 J/cm(2) at four hours (PDT100; n = 13); (b) ALA-PDT as a fractionated dose of 20 and 100 J/cm(2) at one and four hours, respectively (PDT20+ 100; n = 13); or ( c) APC at a power setting of 65 W in two sessions (APC; n = 14). If complete elimination of BO was not achieved by the designated treatment, the remaining BO was treated by a maximum of two sessions of APC.Results: Mean endoscopic reduction of BO at six weeks was 51% (range 20-100%) in the PDT100 group, 86% (range 0-100%) in the PDT20+ 100 group, and 93% (range 40-100%) in the APC group (PDT100 v PDT20+ 100, p