Familial influences on basal salivary cortisol in an adult population
Familial influences on basal salivary cortisol in an adult population
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DOI：
10.1016/j.psyneuen.2005.04.003
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发表时间：
2005-10-01
影响因子：
3.7
通讯作者：
Willemsen, G
中科院分区：
文献类型：
--
作者：
Kupper, N;de Geus, EJC;Willemsen, G
为了了解基础皮质醇水平个体差异的潜在遗传和环境来源，我们收集了成年双胞胎及其单胞胎兄弟姐妹在觉醒时和白天六个固定时间点的唾液皮质醇。报告的觉醒时间与心率和身体运动记录进行了验证。来自309个双胞胎家庭的199个MZ双胞胎，272个DZ双胞胎和229个单胞胎兄弟姐妹的皮质醇数据可用。双胞胎和独生子女之间的皮质醇均值和方差无差异。此外，DZ双胞胎和兄弟姐妹的相关性没有显着差异，表明双胞胎研究结果的一般性。人口遗传模型拟合显示，皮质醇水平在觉醒期间的遗传性（34%的皮质醇水平在觉醒后30分钟的皮质醇水平和32%的皮质醇水平在觉醒后），但不是皮质醇水平在白天晚些时候。目前的研究表明，虽然觉醒期的皮质醇水平受到遗传因素的影响，但一天中大部分时间的皮质醇水平都是不可遗传的，这表明未来基础皮质醇的基因发现研究应该集中在觉醒后的第一个小时。(c)2005爱思唯尔有限公司保留所有权利。
To understand the underlying genetic and environmental sources of individual variation in basal cortisol levels, we collected salivary cortisol at awakening and at six fixed time points during the day in adult twins and their singleton siblings. Reported time of awakening was verified with heart rate and body movement recordings. Cortisol data were available for 199 MZ twins, 272 DZ twins and 229 singleton siblings from 309 twin families. No differences in cortisol means and variances were found between twins and singleton siblings. Additionally, the correlations for DZ twins and siblings were not significantly different, indicating generalizability of twin study results to the general. population. Genetic model fitting showed heritability for cortisol levels during the awakening period (34% for cortisol level at awakening and 32% for cortisol level at 30 min after awakening) but not for cortisol levels later during the day. The current study shows that, while cortisol levels in the awakening period are influenced by genetic factors, cortisol levels throughout most of the day are not heritable, indicating that future gene finding studies for basal cortison should focus on the first hour post-awakening. (c) 2005 Elsevier Ltd. All rights reserved.