Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study.
Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study.
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在Prebone-Kids研究中，与马来西亚前儿童的骨骼健康状况相关的因素。
DOI：
10.1186/s12887-021-02842-6
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发表时间：
2021-09-03
期刊：
影响因子：
2.4
通讯作者：
Chee WSS
中科院分区：
文献类型：
--
作者：
Chang CY;Arasu K;Wong SY;Ong SH;Yang WY;Chong MHZ;Mavinkurve M;Khoo EJ;Chinna K;Weaver CM;Chee WSS
可改变的生活方式因素和身体成分会影响儿童时期达到峰值骨量。本研究对吉隆坡（PREBONE-儿童研究）青少年前（N = 243）马来西亚儿童的骨骼健康决定因素进行了横断面分析，这些儿童习惯性低钙摄入量和维生素D水平。采用双能X线骨密度仪（DXA）评估腰椎（LS）和全身（TB）的身体成分、骨密度（BMD）和骨矿物质含量（BMC）。使用1周饮食史评估钙摄入量，使用cPAQ体力活动问卷评估MET（任务代谢当量）评分，使用LC-MS/MS评估血清25（OH）维生素D。平均钙摄入量为349 ± 180 mg/天，平均血清25（OH）D水平为43.9 ± 14.5 nmol/L。在男孩中，瘦体重（LM）是LSBMC（β = 0.539，p < 0.001）、LSBMD（β = 0.607，p < 0.001）、TBBMC（β = 0.675，p < 0.001）和TBBMD（β = 0.481，p < 0.01）的显著预测因子。身高是LSBMC（β = 0.346，p < 0.001）和TBBMC（β = 0.282，p < 0.001）的显著预测因子，而脂肪量（FM）（β = 0.261，p = 0.034）和以MET评分衡量的体力活动（β = 0.163，p = 0.026）是男孩TBBMD的显著预测因子。在女孩中，LM也是LSBMC（β = 0.620，p < 0.001）、LSBMD（β = 0.700，p < 0.001）、TBBMC（β = 0.542，p < 0.001）和TBBMD（β = 0.747，p < 0.001）的显著预测因子。钙摄入量是女孩LSBMC（β = 0.102，p = 0.034）、TBBMC（β = 0.122，p < 0.001）和TBBMD（β = 0.196，p = 0.002）的显著预测因子。LM是青春期前马来西亚儿童BMC和BMD的主要决定因素，以及其他可改变的生活方式因素，如体力活动和钙摄入量。
Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent (N = 243) Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study). Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ physical activity questionnaire, and serum 25(OH) vitamin D using LC-MS/MS. The mean calcium intake was 349 ± 180 mg/day and mean serum 25(OH)D level was 43.9 ± 14.5 nmol/L. In boys, lean mass (LM) was a significant predictor of LSBMC (β = 0.539, p < 0.001), LSBMD (β = 0.607, p < 0.001), TBBMC (β = 0.675, p < 0.001) and TBBMD (β = 0.481, p < 0.01). Height was a significant predictor of LSBMC (β = 0.346, p < 0.001) and TBBMC (β = 0.282, p < 0.001) while fat mass (FM) (β = 0.261, p = 0.034) and physical activity measured as MET scores (β = 0.163, p = 0.026) were significant predictors of TBBMD in boys. Among girls, LM was also a significant predictor of LSBMC (β = 0.620, p < 0.001), LSBMD (β = 0.700, p < 0.001), TBBMC (β = 0.542, p < 0.001) and TBBMD (β = 0.747, p < 0.001). Calcium intake was a significant predictor of LSBMC (β = 0.102, p = 0.034), TBBMC (β = 0.122, p < 0.001) and TBBMD (β = 0.196, p = 0.002) in girls. LM was the major determinant of BMC and BMD among pre-adolescent Malaysian children alongside other modifiable lifestyle factors such as physical activity and calcium intake.