Antibiotic resistance in Aeromonas hydrophila and Vibrio alginolyticus isolated from a wound infection:: A case report
Antibiotic resistance in Aeromonas hydrophila and Vibrio alginolyticus isolated from a wound infection:: A case report
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DOI：
10.1097/01.ta.0000066381.33339.c0
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发表时间：
2005-01-01
影响因子：
--
通讯作者：
Maekawa, M
中科院分区：
文献类型：
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作者：
Horii, T;Morita, M;Maekawa, M
嗜水气单胞菌是一种活动的、非产孢的、发酵的、兼性的、厌氧的革兰氏阴性杆菌，常见于淡水、自来水、土壤和游泳池中。（1，2）由气单胞菌属引起的人类感染通常与水生环境中的创伤、（3-7）免疫抑制、（7）和慢性疾病有关。(8)气单胞菌属中的β-内酰胺耐药性已经被报道了。(9)在临床气单胞菌分离株中，β-内酰胺酶基因的遗传特性已得到表征。（9-12）以前的报道（9，13）表明气单胞菌属（Aeromonasspp.）可产生多种β-内酰胺酶，包括碳青霉烯水解金属β-内酰胺酶，这是抗生素治疗的一个重要问题。溶藻弧菌是一种兼性厌氧的革兰氏阴性杆菌，具有用于移动的单极鞭毛。(14)溶藻弧菌是一种嗜盐细菌，广泛存在于世界各地的沿海沃茨和沉积物中。(15)由溶藻弧菌引起的人类感染包括耳部、软组织和伤口感染。(14最近的报道（18）显示，从环境中分离的40%的溶藻弧菌产生赋予氨苄青霉素抗性的β-内酰胺酶。溶藻弧菌的抗生素耐药性是与水环境相关的伤口感染的一个重要问题。与水生环境有关的藻酸弧菌和溶藻弧菌。遗传分析表明，微生物检查是至关重要的，因为这些水环境相关的菌株有多种抗生素耐药性的决定因素。
Aeromonas hydrophila is a motile, nonsporulating, fermentative, facultative, anaerobic, gram-negative bacillus commonly found in fresh water, tap water, soil, and swimming pools.(1,2) Human infections caused by Aeromonas spp. are frequently associated with trauma in the aquatic environment,(3-7) immunosuppression,(7) and chronic disease.(8) beta-Lactam resistance in Aeromonas spp. has been reported.(9) In clinical Aeromonas isolates, genetic properties of the beta-lactamase genes have been characterized.(9-12) Previous reports(9,13) demonstrated that Aeromonas spp. can produce multiple beta-lactamases, including a carbapenem-hydrolyzing metallo-beta-lactamase, which is an important problem for antibiotic treatment.Vibrio alginolyticus is a facultatively anaerobic, gram-negative bacillus with a single polar flagellum for mobility.(14) V. alginolyticus, a halophilic bacterium, is common in coastal waters and sediments all over the world.(15) Human infections caused by V. alginolyticus include ear, soft tissue, and wound infections.(14,16-17) Recent reports(18) showed that 40% of V. alginolyticus isolated from the environment produce beta-lactamases conferring resistance to ampicillin. Antibiotic resistance in V. alginolyticus is a significant problem for wound infections related to the aquatic environment.We describe a wound infection caused by both A. hydrophila and V. alginolyticus related to an aquatic environment. Genetic analysis suggests that microbiologic examination is critical, because these aquatic environment-related isolates had a variety of determinants of antibiotic resistance.