Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study.
Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study.
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依托泊苷和阿糖胞苷（EC 方案）对淋巴瘤患者进行有效的化疗：一项单中心、回顾性、观察性研究。
DOI：
10.1093/jjco/hyx076
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发表时间：
2017
影响因子：
2.4
通讯作者：
Sugiura I
中科院分区：
文献类型：
--
作者：
Koyama D;Nishiwaki S;Harada Y;Yamamoto S;Kurahashi S;Sugimoto T;Iwasaki T;Sugiura I
自体造血干细胞移植是治疗复发或难治性淋巴瘤的重要策略。虽然已经使用了各种外周血干细胞采集方案，但尚未建立最佳方案。我们的目的是评价由依托泊苷和阿糖胞苷组成的方案的动员效果和安全性方法回顾性分析46例淋巴瘤患者采用EC方案[依托泊苷]进行外周血干细胞动员的临床资料阿糖胞苷（100 mg/m2/d，第1-4天）和阿糖胞苷（100 mg/m2/d，第1-4天）。最常见的基础疾病是弥漫性大B细胞淋巴瘤（46%）和滤泡性淋巴瘤（26%）。四分之三的患者处于第二次完全或部分缓解。采集的CD 34+细胞总数中位数为10.6 × 106 kg-1。42例患者（91%）在中位2个单采日内产生至少2 × 106 kg-1CD 34+细胞，33例患者（72%）仅通过一次单采即可达到此目的。在先前未能动员的6例患者中，有5例观察到成功动员。虽然发热性中性粒细胞减少发生在22例（48%），没有致命的感染observed.ConclusionThe EC方案是非常有效的淋巴瘤患者，包括动员与其他方案差的患者。
ObjectiveAutologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).MethodsWe retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1–4) and cytarabine (100 mg/m2/day, days 1–4)] at Toyohashi municipal hospital from 2004 to 2013.ResultsThe median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+cells was 10.6 × 106kg–1. Forty-two patients (91%) yielded at least 2 × 106kg–1CD34+cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.ConclusionThe EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.