Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease.
Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease.
复制标题
盐酸多奈哌齐可以保护阿尔茨海默病患者的局部脑血流。
DOI：
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发表时间：
2001
影响因子：
9.3
通讯作者：
M. Takasaki
中科院分区：
文献类型：
--
作者：
S. Nakano;T. Asada;H. Matsuda;M. Uno;M. Takasaki
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本研究的目的是利用统计参数图研究多奈哌齐对轻中度阿尔茨海默病(AD)患者局部脑血流量(RCBF)的影响。
方法
用~(99m)Tc-半胱酸乙酯二聚体对35例初步评定为16分的AD患者进行了rCBF无创性测定。对这些患者进行基线和随访SPECT检查，平均间隔12个月。我们使用调整后的相对血流分布的rCBF图像(将每个患者的全球脑血流量归一化为50mL/100g/min，按比例缩放)，通过统计参数映射来比较这些组。
结果
在随访研究中，与安慰剂治疗的AD患者相比，接受多奈哌齐治疗的AD患者调整后的rCBF在右侧和左侧扣带回前回、右侧颞中回、右侧顶下小叶和前额叶显著保留。
结论
多奈哌齐治疗1年似乎减少了rCBF的下降，提示保留了脑功能活动。
UNLABELLED
The aim of this SPECT study was to investigate the effects of donepezil on regional cerebral blood flow (rCBF) in patients with mild to moderate Alzheimer's disease (AD) using statistical parametric mapping.
METHODS
rCBF was noninvasively measured using (99m)Tc-ethyl cysteinate dimer in 35 AD patients with a Mini-Mental State Examination score > 16 on initial evaluation. Baseline and follow-up SPECT studies with a mean interval of 12 mo were performed on these patients. We used the adjusted rCBF images in the relative flow distribution (normalization of global cerebral blood flow for each patient to 50 mL/100 g/min with proportional scaling) to compare these groups through statistical parametric mapping.
RESULTS
In the follow-up study, the adjusted rCBF was significantly preserved in the right and left anterior cingulate gyri, right middle temporal gyrus, right inferior parietal lobules, and prefrontal cortex of donepezil-treated AD patients, compared with placebo-treated AD patients.
CONCLUSION
Treatment with donepezil for 1 y appears to reduce the decline in rCBF, suggesting preservation of functional brain activity.
DOI：
10.1073/pnas.87.1.256
发表时间：
1990-01-01
影响因子：
11.1
作者：
PARDO, JV;PARDO, PJ;RAICHLE, ME
通讯作者：
RAICHLE, ME