Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.
Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.
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DOI：
10.1007/s10552-009-9427-7
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发表时间：
2009-11
影响因子：
2.3
通讯作者：
Platz, Elizabeth A.
中科院分区：
文献类型：
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作者：
Tsilidis, Konstantinos K.;Helzlsouer, Kathy J.;Smith, Michael W.;Grinberg, Victoriya;Hoffman-Bolton, Judith;Clipp, Sandra L.;Visvanathan, Kala;Platz, Elizabeth A.
研究人员研究了 IL10 和其他免疫反应基因（CRP、TLR4、IL6、IL1B、IL8、TNF、RNASEL）以及肥胖相关基因（PPARG、TCF7L2、ADIPOQ、LEP）中 17 个候选单核苷酸多态性 (SNP) 与结直肠癌的关联。为 IL10、CRP 和 TLR4 选择单倍型标记 SNP。在 1989 年至 2003 年基线期间，在 CLUE II 队列参与者中确定了结直肠癌发病病例 (n = 208) 和匹配对照 (n = 381)。使用条件逻辑回归估计优势比 (OR) 和 95% 置信区间 (95% CI)。与候选 IL10-1082 位点 (rs1800896) 的 AA 基因型相比，携带一个 (OR, 0.79; 95% CI, 0.53–1.18) 或两个 (OR, 0.58; 95% CI, 0.35–0.95) G 等位基因（已知抗炎细胞因子 IL-10 的较高产生者）与结直肠癌风险较低相关。癌症（ptrend = 0.03）。 IL10 中的 3 个 tagSNP（rs1800890、rs3024496、rs3024498）和一种常见单倍型与结直肠癌存在统计学显着关联，但这些关联是由于与 IL10-1082 的高度连锁不平衡所致。两种 CRP 单倍型（总体 p = 0.04）和 TLR4 tagSNP（rs7873784、rs11536891）与结直肠癌相关，但 TLR4 单倍型则不然。我们的研究表明，IL10 的多态性以及 CRP 和其他与免疫反应或肥胖相关的基因的多态性可能与结直肠癌有关。
The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated. Haplotype tagging SNPs were chosen for IL10, CRP, and TLR4. Incident colorectal cancer cases (n = 208) and matched controls (n = 381) were identified between baseline in 1989 and 2003 among participants in the CLUE II cohort. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression. Compared with the AA genotype at the candidate IL10-1082 locus (rs1800896), carrying one (OR, 0.79; 95% CI, 0.53–1.18) or two (OR, 0.58; 95% CI, 0.35–0.95) G alleles, a known higher producer of the anti-inflammatory cytokine IL-10, was associated with lower risk of colorectal cancer (ptrend = 0.03). Statistically significant associations with colorectal cancer were observed for three tagSNPs in IL10 (rs1800890, rs3024496, rs3024498) and one common haplotype, but these associations were due to high linkage disequilibrium with IL10-1082. Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer. Our study suggests that polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
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影响因子：
5.8
作者：
Ferrari, SL;Ahn-Luong, L;Greenspan, SL
通讯作者：
Greenspan, SL
影响因子：
4.9
作者：
Hager, J;Clement, K;Froguel, P
通讯作者：
Froguel, P
影响因子：
16.2
作者：
Folsom, Aaron R.;Pankow, James S.;Boerwinkle, Eric
通讯作者：
Boerwinkle, Eric
DOI：
10.1089/154099903321576574
发表时间：
2003-03-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Giovannucci, E
通讯作者：
Giovannucci, E
影响因子：
15.9
作者：
Fishman, D;Faulds, G;Woo, P
通讯作者：
Woo, P