Hypothyroidism coordinately and transiently affects myelin protein gene expression in most rat brain regions during postnatal development
Hypothyroidism coordinately and transiently affects myelin protein gene expression in most rat brain regions during postnatal development
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DOI：
10.1016/s0006-8993(96)01480-1
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发表时间：
1997-03-28
期刊：
影响因子：
2.9
通讯作者：
RodriguezPena, A
中科院分区：
文献类型：
--
作者：
Ibarrola, N;RodriguezPena, A
为了评估甲状腺激素对髓鞘基因表达的作用，我们研究了甲状腺功能减退症对出生后第一个月内大鼠不同脑区主要髓鞘蛋白基因：髓鞘碱性蛋白（MBP）、蛋白脂质蛋白（PLP）、髓鞘相关糖蛋白（MAG）和2 '：3'-环核苷酸3 '-磷酸二酯酶（CNP）mRNA稳态水平的影响。我们发现，甲状腺功能减退症降低了每一种髓鞘蛋白质转录物的水平，不同大脑区域之间存在显著差异。因此，在更尾部的区域，甲状腺功能减退的影响是非常温和的，只在髓鞘形成的早期阶段明显。相反，在纹状体和大脑皮层中，髓鞘蛋白转录物的重要减少在出生后的第一个月后仍然存在。因此，甲状腺激素以同步方式调节髓鞘基因的表达，其作用的长度取决于大脑区域。另一方面，甲状腺功能亢进导致主要髓鞘蛋白转录物高于对照值的增加。最后，甲状腺激素缺乏不会改变少突胶质细胞祖细胞特异性基因血小板衍生生长因子受体α的表达。(C)1997年Elsevier Science B.V.
To assess the role of thyroid hormone on myelin gene expression, we have studied the effect of hypothyroidism on the mRNA steady state levels for the major myelin protein genes: myelin basic protein (MBP), proteolipid protein (PLP), myelin-associated glycoprotein (MAG) and 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNP) in different rat brain regions, during the first postnatal month. We found that hypothyroidism reduces the levels of every myelin protein transcript, with striking differences between the different brain regions. Thus, in the more caudal regions, the effect of hypothyroidism was extremely modest, being only evident at the earlier stages of myelination. In contrast, in the striatum and the cerebral cortex the important decrease in the myelin protein transcripts is maintained beyond the first postnatal month. Therefore, thyroid hormone modulates in a synchronous fashion the expression of the myelin genes and the length of its effect depends on the brain region. On the other hand, hyperthyroidism leads to an increase of the major myelin protein transcripts above control values. Finally, lack of thyroid hormone does not change the expression of the oligodendrocyte progenitor-specific gene, the platelet derived growth factor receptor alpha. (C) 1997 Elsevier Science B.V.