Airway hyperreactivity: assessment with helical thin-section CT.
Airway hyperreactivity: assessment with helical thin-section CT.
复制标题
气道高反应性：螺旋薄层 CT 评估。
DOI：
10.1148/radiology.208.2.9680554
复制
发表时间：
1998
期刊：
影响因子：
19.7
通讯作者：
Aberle,DR
中科院分区：
文献类型：
--
作者：
Goldin,JG;McNitt-Gray,MF;Sorenson,SM;Johnson,TD;Dauphinee,B;Kleerup,EC;Tashkin,DP;Aberle,DR
目的探讨螺旋计算机断层扫描（CT）在评估气道高反应性引起的可逆性支气管大小变化和空气捕获方面的准确性。材料与方法对15例轻度哮喘患者和6例健康对照者进行肺活量测定和螺旋CT检查。在两个肺区（隆突上方和下方）进行暂停功能残余容量和残余容量CT检查。比较支气管面积和肺衰减测量值。结果基线时，对照组与哮喘组肺衰减频率分布曲线相似。服用甲胆碱后，对照组1秒用力呼气量（FEV1）下降幅度小于10%，肺衰减曲线差异无统计学意义。哮喘患者FEV1下降20%-36%，衰减曲线中位数和最低10个百分位数区域以及小气道（< 5-mm2）横截面积显著下降（所有比较P < 0.001）。服用沙丁胺醇后，对照受试者的肺活量测量、肺衰减或支气管大小没有变化，而哮喘患者的所有这些参数都恢复到基线水平。结论功能螺旋CT能准确显示气道高反应性引起的可逆性气流阻塞。
PURPOSETo determine the accuracy of helical computed tomography (CT) for assessing reversible changes in bronchial size and air trapping due to airway hyperreactivity.MATERIALS AND METHODSSpirometry and helical CT were performed in 15 patients with mild asthma and six healthy control subjects before and after bronchial provocation with methacholine chloride and after reversal of provocation with albuterol. CT was performed at suspended functional residual capacity and at residual volume in two lung regions (above and below the carina). Bronchial area and lung attenuation measurements were compared.RESULTSAt baseline, lung attenuation frequency distribution curves were similar between the control and asthma groups. After methacholine, control subjects showed a decrease of less than 10% in the forced expiratory volume at 1 second (FEV1) and no significant differences in lung attenuation curves. Patients with asthma showed a 20%-36% decrease in FEV1, with significant decreases in the median and lowest 10th percentile regions of the attenuation curves and in the cross-sectional area of small (< 5-mm2) airways (P < .001 for all comparisons). After albuterol, control subjects showed no change in spirometric measurements, lung attenuation, or bronchial size, whereas all such parameters returned to baseline levels in patients with asthma.CONCLUSIONFunctional helical CT can accurately demonstrate reversible airflow obstruction resulting from airway hyperreactivity.