CHANGES IN THE DURATION OF THE ELECTRIC RESPONSE OF SINGLE NERVE FIBERS FOLLOWING REPETITIVE STIMULATION
CHANGES IN THE DURATION OF THE ELECTRIC RESPONSE OF SINGLE NERVE FIBERS FOLLOWING REPETITIVE STIMULATION
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DOI：
10.1085/jgp.40.1.19
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发表时间：
1956-01-01
影响因子：
3.8
通讯作者：
SPYROPOULOS, CS
中科院分区：
文献类型：
--
作者：
SPYROPOULOS, CS
从支配蟾蜍缝匠肌或半腱肌的神经中分离出单根神经纤维。响应记录与3个安排的“桥绝缘体”的方法。在以50-150脉冲/秒刺激20-140分钟期间，尖峰持续时间逐渐增加。破伤风后，尖峰持续时间通常继续以更快的速度增加。在5-60分钟内，进一步延长停止，在1-10小时内，尖峰持续时间正常。强直纤维的反应持续时间是未强直纤维的尖峰持续时间的2.5倍至10倍以上。在从体内强直的神经分离的神经纤维中观察到延长。
Single nerve fibers were isolated from the nerve innervating the sartorius or semitendi-nosus muscle of the toad (Bufo marinus). Responses were recorded with 3 arrangements of the "bridge-insulator" method. During stimulation at 50-150 pulses/second for 20-140 minutes the spike duration was progressively increased. After tetanization, the spike duration usually continued to increase at a more rapid rate. Within 5-60 minutes further prolongation stopped and within 1-10 hours the spike duration was normal. The duration of the response of tetanized fibers was from 2.5 to more than 10 times the spike duration of untetanized fibers. Prolongation was seen in nerve fibers isolated from nerves tetanized in vivo.