Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy.
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy.
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DOI：
10.1016/j.cmet.2023.06.003
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发表时间：
2023-06
期刊：
影响因子：
29
通讯作者：
Weiping Zou;D. Green
中科院分区：
文献类型：
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作者：
Weiping Zou;D. Green
肿瘤微环境（TME）中的代谢编程改变了荷瘤小鼠和癌症患者的肿瘤免疫和免疫治疗反应。在这里，我们回顾了 TME 中核心代谢途径、关键代谢物和关键营养转运蛋白的免疫相关功能，讨论了它们对肿瘤免疫和免疫治疗的代谢、信号传导和表观遗传影响，并探讨了如何将这些见解应用于开发更有效的方法，以增强 T 细胞的功能并使肿瘤细胞对免疫攻击的接受性敏感，从而克服治疗耐药性。
Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we review immune-related functions of core metabolic pathways, key metabolites, and crucial nutrient transporters in the TME, discuss their metabolic, signaling, and epigenetic impact on tumor immunity and immunotherapy, and explore how these insights can be applied to the development of more effective modalities to potentiate the function of T cells and sensitize tumor cell receptivity to immune attack, thereby overcoming therapeutic resistance.