ESTIMATION OF RENAL TUBULAR SECRETION IN MAN, IN HEALTH AND DISEASE, USING ENDOGENOUS N-1-METHYLNICOTINAMIDE
ESTIMATION OF RENAL TUBULAR SECRETION IN MAN, IN HEALTH AND DISEASE, USING ENDOGENOUS N-1-METHYLNICOTINAMIDE
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DOI：
10.1159/000186698
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发表时间：
1992-01-01
期刊：
影响因子：
2.5
通讯作者：
DALEYYATES, PT
中科院分区：
文献类型：
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作者：
MAIZA, A;WALDEK, S;DALEYYATES, PT
我们一直在研究使用内源性N-1-甲基烟酰胺(NMN)的肾脏清除率作为肾小管功能标志物的可能性。研究对象为63名受试者(11名健康志愿者和52名肾功能损害患者)。根据内生肌酐清除量将受试者分为3组：1组，>80ml/min；2组，在30~80ml/min之间；3组，<30ml/min。比较各组NMN与内生肌酐清除率的相关性。第1、3组相关性好(r=0.76)，第2组相关性差(r=0.43)。对于轻度肾损害受试者(第2组)，有明确的证据表明肾小球-肾小管失衡，表现为NMN清除量的变异性大于肌酐清除量，这两个参数在该组基本上不平行下降。当所有受试者分组时，NMN清除量与肌酐清除量之间的关系可用三项多项式方程来描述(r=0.93)。NMN清除率是一种潜在有用的非侵入性指标，可作为人体肾小管功能的非侵入性标记物，并可为肌酐清除率的测定提供更多信息。应该更充分地评估这种物质作为一种潜在的诊断辅助手段。
We have been investigating the possibility of using the renal clearance of endogenous N-1-methylnicotinamide (NMN) as a marker of renal tubular function. Sixty-three subjects (11 healthy volunteers and 52 patients with renal impairment) were used for this study. The subjects were divided into three groups according to their creatinine clearance: group 1, over 80 ml/min; group 2, between 30 and 80 ml/min, and group 3, less than 30 ml/min. The correlation between NMN and creatinine clearance was compared for each group. A good correlation (r = 0.84) was found for groups 1 and 3 (r = 0.76), whereas for group 2, a poor correlation was found (r = 0.43). For subjects with mild renal impairment (group 2), there was clear evidence of glomerulo-tubular imbalance manifest by a larger variability in NMN clearance than creatinine clearance and an essentially non-parallel decline in these two parameters for this group. When all subjects were grouped together, the relationship between the clearance of NMN and of creatinine was best described by a 3-term polynomial equation (r = 0.93). NMN clearance is a potentially useful non-invasive marker of renal tubular function in man and provides additional information to that provided by the measurement of creatinine clearance alone. This substance should be more fully evaluated as a potential diagnostic aid.