PLACENTAL GLYCOLYSIS AND ENERGY-METABOLISM IN PREECLAMPSIA
PLACENTAL GLYCOLYSIS AND ENERGY-METABOLISM IN PREECLAMPSIA
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DOI：
10.1016/s0002-9378(87)80354-x
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发表时间：
1987-07-01
影响因子：
9.8
通讯作者：
LAO, TT
中科院分区：
文献类型：
--
作者：
BLOXAM, DL;BULLEN, BE;LAO, TT
我们研究了先兆子痫合并胎儿生长迟缓时，胎盘能量阶段低的可能性，这可能是由于糖酵解受损或母体胎盘血流减少导致的缺血所致。丙酮酸和乳酸的浓度，但不是糖原和葡萄糖，在重度子痫前期母亲的胎盘显着低，支持以前的间接证据抑制糖酵解。然而，腺嘌呤核苷酸浓度的直接测量并没有表明降低胎盘能量水平在先兆子痫胎盘。这沿着乳酸盐/丙酮酸盐浓度比（细胞质还原型烟酰胺腺嘌呤二核苷酸/烟酰胺腺嘌呤二核苷酸的氧化还原状态的指示）缺乏变化，也是反对一般胎盘缺血导致能量缺乏的假设的证据。然而，由于糖酵解是合成氨基酸和脂质的前体，特别是丙酮酸的重要来源，这些结果表明，重度先兆子痫母亲的胎盘中存在显著的代谢异常。
We examined the possiiblity that in preeclampsiacomplicated by fetal growth retardation, placental energy stage is low either because of impaired glycolysis or because of ischemia resulting from reduced maternal placental blood flow. Concentrations of pyruvate and lactate, but not of glycogen and glucose, were significantly low in placentas of mothers with severe preeclampsia, supporting previous indirect evidence of inhibited glycolysis. Nevertheless, direct measurements of adenine nucleotide concentrations did not indicate reduced placental energy level in the preeclamptic placentas. This along with a lack of change of the ratio of lactate/pyruvate concentration (an indication of the redox state of cytoplasmic reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide) is also evidence against the hypothesis of general placental ischaemia leading to energy deficiency. However, as glycolysis is an important source of precursors, particularly pyruvate, for synthesis of amino acids and lipids, these results suggest that there is a significant metabolic abnormality in placentas of mothers with severe preeclampsia.