Best practices to promote rigor and reproducibility in the era of sex-inclusive research.
Best practices to promote rigor and reproducibility in the era of sex-inclusive research.
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DOI：
10.7554/elife.90623
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发表时间：
2023-11-02
期刊：
影响因子：
7.7
通讯作者：
Maney DL
中科院分区：
文献类型：
--
作者：
Rich-Edwards JW;Maney DL
为了提高包容性和严谨性，许多资助机构和期刊现在要求将女性和男性纳入生物医学研究。这些任务加强了普遍性，为发现性别差异创造了前所未有的机会。然而，将性别视为一个亚组类别的正确方法的教育已经落后，导致了一个有问题的文献，其中研究设计，分析和结果的解释往往是有缺陷的。在这里，我们概述了遵守性别包容性的任务，无论是在研究中，性别差异是一个主要的焦点，并为那些在他们不是最好的做法。我们的建议是在美国国立卫生研究院妇女健康研究办公室制定的“研究性以加强科学的4个C：考虑、收集、表征和交流”框架内提出的。遵循这些指导方针应该有助于研究人员在他们的研究中包括女性和男性，同时坚持高标准的严谨性。
To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex differences. Education in sound methods to consider sex as a subgroup category has lagged behind, however, resulting in a problematic literature in which study designs, analyses, and interpretations of results are often flawed. Here, we outline best practices for complying with sex-inclusive mandates, both for studies in which sex differences are a primary focus and for those in which they are not. Our recommendations are organized within the “4 Cs of Studying Sex to Strengthen Science: Consideration, Collection, Characterization and Communication,” a framework developed by the Office of Research on Women’s Health at the National Institutes of Health in the United States. Following these guidelines should help researchers include females and males in their studies while at the same time upholding high standards of rigor.