Flagellar kinematics reveals the role of environment in shaping sperm motility
Flagellar kinematics reveals the role of environment in shaping sperm motility
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DOI：
10.1098/rsif.2020.0525
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发表时间：
2020-09-30
影响因子：
3.9
通讯作者：
Stocker, Roman
中科院分区：
文献类型：
--
作者：
Guasto, Jeffrey S.;Estrada, Jonathan B.;Stocker, Roman
来自不同生物体的游动精子通常具有非常相似的形态，但由于用于推进的鞭毛波形的差异而导致不同的运动力。这些差异的根源仍然很大程度上未知。使用高速视频显微镜和鞭毛形状动力学的数学分析，我们通过一种新颖的系统运动树定量比较海洋无脊椎动物和人类的精子鞭毛波形。这种新方法揭示了遗传上不同的精子可以表现出惊人相似的鞭毛波形，并在此处研究的后口动物中识别出两种主要的鞭毛波形，分别对应于内部和外部肥料。系统运动树与系统发育树显示出明显的不一致，这表明流体环境的物理特性，不仅仅是遗传相关性，在塑造精子活力的进化过程中起着重要的选择压力的作用。更广泛地说，这项工作提供了一个物理轴来补充形态学和遗传学研究，以了解进化关系。
Swimming spermatozoa from diverse organisms often have very similar morphologies, yet different motilities as a result of differences in the flagellar waveforms used for propulsion. The origin of these differences has remained largely unknown. Using high-speed video microscopy and mathematical analysis of flagellar shape dynamics, we quantitatively compare sperm flagellar waveforms from marine invertebrates to humans by means of a novel phylokinematic tree. This new approach revealed that genetically dissimilar sperm can exhibit strikingly similar flagellar waveforms and identifies two dominant flagellar waveforms among the deuterostomes studied here, corresponding to internal and external fertilizers. The phylokinematic tree shows marked discordance from the phylogenetic tree, indicating that physical properties of the fluid environment, more than genetic relatedness, act as an important selective pressure in shaping the evolution of sperm motility. More broadly, this work provides a physical axis to complement morphological and genetic studies to understand evolutionary relationships.