Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer
Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer
复制标题
DOI：
10.1016/j.cellbi.2005.04.004
复制
发表时间：
2005-08-01
影响因子：
3.9
通讯作者：
Daoud, SA
中科院分区：
文献类型：
--
作者：
Amin, A;Alkaabi, A;Daoud, SA
癌症是全球第二大死因。传统疗法会导致严重的副作用，充其量只能将患者的寿命延长几年。因此，癌症控制可能受益于替代疗法的潜力。因此，越来越多的人需要利用替代概念或方法来预防癌症。在这份报告中，我们展示了胡芦巴种子对7，12-二甲基苯(α)菲(DMBA)诱导的大鼠乳腺癌的潜在保护作用。胡芦巴提取物200 mg/kgb.wt可显著抑制DMBA所致小鼠乳腺增生，降低其发生率。流行病学研究还表明，细胞凋亡可能是胡芦巴抗乳腺癌保护作用的一种机制。据我们所知，这是第一项表明胡芦巴种子对乳腺癌有显著化学预防作用的研究。(C)2005年国际细胞生物学联合会。爱思唯尔有限公司出版。保留所有权利。
Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects and, at best, merely extend the patient's lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. There is thus an increasing demand to utilize alternative concepts or approaches to the prevention of cancer. In this report,,we show a potential protective effect of Fenugreek seeds against 7,12-dimethylbenz(alpha)anthracene (DMBA)-induced breast cancer in rats. At 200 mg/kg b.wt., Fenugreek seeds' extract significantly inhibited the DMBA-induced mammary hyperplasia and decreased its incidence. Epidemiological studies also implicate apoptosis as a mechanism that might mediate the Fenugreek's antibreast cancer protective effects. To our knowledge, this is the first study that suggests significant chemopreventive effects of Fenugreek seeds against breast cancer. (c) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.