Metabolic fate of chromium compounds. I. Comparative behavior of chromium in rat administered with Na251CrO4 and 51CrCl3.
Metabolic fate of chromium compounds. I. Comparative behavior of chromium in rat administered with Na251CrO4 and 51CrCl3.
复制标题
铬化合物的代谢命运。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
M. Ando
中科院分区：
文献类型：
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作者：
Y. Sayato;K. Nakamuro;S. Matsui;M. Ando
比较标记的氯化铬和铬酸钠的代谢命运和这些化合物在大鼠肝脏和血液中的相互作用进行了研究，口服和静脉给药后。两种化合物的胃肠道吸收均低于口服剂量的1%，但大鼠体内三价铬的放射性高于六价铬（生物半衰期：CrCl 3 91.79天，Na2CrO 4 22.24天）。静脉给药后也观察到三价铬的较高残留活性。静脉给药后，两种形式的铬通过肾脏在尿液中的排泄量大于肠道中的排泄量。当51CrCl_3和Na_（251）CrO_4被注射到大鼠体内时，在51Cr在器官中的时间分布模式中，两种化合物的氧化态之间显示出显著的差异，尤其是在肝脏和血液成分的亚细胞组分中。在大鼠血液中观察到的这种显著差异主要来自三价铬对血浆中的转铁蛋白具有高结合活性，而六价铬可渗透到红细胞中并与血红蛋白结合。
Comparative metabolic fate of labelled chromium chloride and sodium chromate and interaction of these compounds in the rat liver and blood were investigated after their oral and intravenous administration. Gastrointestinal absorption of both compounds was below 1% of the oral dose, but trivalent chromium showed higher radioactivity than the hexavalent form in rats (biological half-life: CrCl3 91.79 days, Na2CrO4 22.24 days). The higher residual activity of the trivalent chromium was also observed after intravenous administration. Both forms of chromium were excreted more in the urine via the kidney than in the intestinal tract after intravenous administration. When 51CrCl3 and Na251CrO4 were injected into rats, in the time-distribution patterns of 51Cr in the organs, a significant difference was shown between oxidation states of the two compounds, especially in subcellular fractions of the liver and blood constituents. This significant difference mainly observed in the rat blood came from the fact that trivalent chromium possessed a high binding activity for transferrin in plasma, while hexavalent chromium was permeable into red cells and bound with hemoglobin.