Solubility of simvastatin and lovastatin in mixtures of dichloromethane and supercritical carbon dioxide
Solubility of simvastatin and lovastatin in mixtures of dichloromethane and supercritical carbon dioxide
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DOI：
10.1021/je700019h
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发表时间：
2007-05
影响因子：
--
通讯作者：
Dong-Joon Oh;Byung-chul Lee;Sung-Joo Hwang
中科院分区：
文献类型：
--
作者：
Dong-Joon Oh;Byung-chul Lee;Sung-Joo Hwang
The phase behavior of simvastatin and lovastatin drugs, which are well-known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dichloromethane (DCM) and supercritical carbon dioxide (CO2) was investigated to present a guideline for establishing operating conditions in the particle formation of the drugs by a supercritical antisolvent recrystallization process utilizing DCM as a solvent and CO2 as an antisolvent. The solubilities of the statin drugs in the DCM + CO2 mixtures were determined as functions of temperature, pressure, and solvent composition by measuring the cloud points of the ternary mixtures of simvastatin + DCM + CO2 and lovastatin + DCM + CO2 at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility data of simvastatin and lovastatin are presented in the mixtures of DCM + CO2 with the DCM mole fractions between 0.18 and 0.34 at temperatures from 303.25 K to 333.25 K and at pressures up to ab...
