Ebolavirus Replication and Tetherin/BST-2.
Ebolavirus Replication and Tetherin/BST-2.
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DOI：
10.3389/fmicb.2012.00111
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发表时间：
2012
影响因子：
5.2
通讯作者：
Yasuda J
中科院分区：
文献类型：
--
作者：
Yasuda J
埃博拉病毒(EbolaVirus，EBOV)是一种囊膜非节段性负链RNA病毒，由扎伊尔埃博拉病毒、苏丹埃博拉病毒、泰林埃博拉病毒、本迪布乔埃博拉病毒和雷斯顿埃博拉病毒五种病毒组成。EBOV在人类和非人类灵长类动物中都会引起致命的出血热。EBOV RNA基因组编码7种病毒蛋白：NP、VP35、VP40、GP、VP30、VP24和L。VP40是一种基质蛋白，是病毒组装和从宿主细胞释放所必需的。VP40在哺乳动物细胞中的表达足以产生细胞外病毒样颗粒，类似于真正的病毒粒子。Tetherin/BST-2被认为是一种有效的细胞因子，可以在没有病毒辅助蛋白VPU的情况下阻止人类免疫缺陷病毒-1的释放，已有报道抑制ZEBOV VP40诱导的VLP释放。Tetherin/BST-2似乎通过其N端跨膜结构域和C端糖基磷脂酰肌醇锚点将病毒颗粒物理地拴在细胞表面来抑制病毒的释放。Tetherin/BST-2的表达不能抑制ZEBOV的复制，尽管Tetherin/BST-2有望抑制EBOV的释放和VLP的释放。最近有报道称，EBOV的病毒糖蛋白GP可拮抗Tetherin/BST-2的抗病毒作用。然而，GP拮抗Tetherin/BST-2的抗病毒活性的机制以及其他EBOV物种的GP是否具有Tetherin/BST-2的拮抗剂作用尚不清楚。
Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus, Sudan ebolavirus, Tai Forest ebolavirus, Bundibugyo ebolavirus, and Reston ebolavirus. EBOV causes a lethal hemorrhagic fever in both humans and non-human primates. The EBOV RNA genome encodes seven viral proteins: NP, VP35, VP40, GP, VP30, VP24, and L. VP40 is a matrix protein and is essential for virus assembly and release from host cells. Expression of VP40 in mammalian cells is sufficient to generate extracellular virus-like particles, which resemble authentic virions. Tetherin/BST-2, which was identified as an effective cellular factor that prevents human immunodeficiency virus-1 release in the absence of viral accessory protein Vpu, has been reported to inhibit ZEBOV VP40-induced VLP release. Tetherin/BST-2 appears to inhibit virus release by physically tethering viral particles to the cell surface via its N-terminal transmembrane domain and C-terminal glycosylphosphatidylinositol anchor. Replication of ZEBOV is not inhibited by tetherin/BST-2 expression, although tetherin/BST-2 was expected to inhibit EBOV release as well as VLP release. Recently, it was reported that viral glycoprotein of EBOV, GP, antagonizes the antiviral effect of tetherin/BST-2. However, the mechanism by which GP antagonizes the antiviral activity of tetherin/BST-2 and whether GP of the other EBOV species function as antagonists of tetherin/BST-2 remain unclear.
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影响因子：
6.4
作者：
Iwasa, Ayaka;Shimojima, Masayuki;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
5.4
作者：
Radoshitzky, Sheli R.;Dong, Lian;Bavari, Sina
通讯作者：
Bavari, Sina
DOI：
10.1073/pnas.0907075106
发表时间：
2009-12-08
影响因子：
11.1
作者：
Gupta, Ravindra K.;Mlcochova, Petra;Towers, Greg J.
通讯作者：
Towers, Greg J.
影响因子：
5.4
作者：
Mansouri, Mandana;Viswanathan, Kasinath;Frueh, Klaus
通讯作者：
Frueh, Klaus
埃博拉病毒 VP40 蛋白中的 PPxY 矩阵与泛素连接酶存在物理和功能上的相互作用： 丝状病毒出芽的意义
DOI：
10.1073/pnas.250277297
发表时间：
2000-12-05
影响因子：
11.1
作者：
Harty, RN;Brown, ME;Hayes, FP
通讯作者：
Hayes, FP