An atlas of mouse mammary gland development
An atlas of mouse mammary gland development
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DOI：
10.1023/a:1026499523505
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发表时间：
2000-04-01
影响因子：
2.5
通讯作者：
Anderson, SM
中科院分区：
文献类型：
--
作者：
Richert, MM;Schwertfeger, KL;Anderson, SM
小鼠乳腺是一个复杂的组织，其结构和功能不断发生变化。胚胎期，腺体开始于一个未发育的导管结构侵入下面的脂肪垫。出生后的生长分为两个阶段：动情周期中的导管生长和早期肺泡发育，以及每次妊娠、哺乳和退化时发生的增殖、分化和死亡周期。在乳腺的整个生命过程中，上皮结构和间质变化的多样性使其研究成为一个挑战。本组织学综述的目的是简要介绍小鼠乳腺发育周期中发生的形态学变化，以便了解小鼠乳腺发育模型中观察到的发育变化。
The mouse mammary gland is a complex tissue, which is continually undergoing changes in structure and function. Embryonically, the gland begins with invasion of the underlying fat pad by a rudimentary ductal structure. Postnatal growth occurs in two phases: ductal growth and early alveolar development during estrous cycles, and cycles of proliferation, differentiation, and death that occur with each pregnancy, lactation, and involution. The variety of epithelial structures and stromal changes throughout the life of a mammary gland makes it a challenge to study. The purpose of this histological review is to give a brief representation of the morphological changes that occur throughout the cycle of mouse mammary gland development so that developmental changes observed in mouse models of mammary development can be appreciated.