Suppression of lordosis in the hormone-primed female hamster by electrical stimulation of the septal area
Suppression of lordosis in the hormone-primed female hamster by electrical stimulation of the septal area
复制标题
通过电刺激间隔区抑制激素引发的雌性仓鼠的脊柱前凸
DOI：
10.1016/0031-9384(75)90187-0
复制
发表时间：
1975
影响因子：
2.9
通讯作者：
D. Pfaff
中科院分区：
文献类型：
--
作者：
N. Zasorin;C. Malsbury;D. Pfaff
雌性仓鼠对雄性仓鼠的行为被雌激素和黄体酮彻底改变。她的攻击性被性接受所取代，在性活跃的男性面前，前倾的姿势通常会保持10分钟以上。中隔区是雌性仓鼠大脑边缘和下丘脑优先积累放射性雌二醇的区域之一。为了确定该区域是否参与前凸控制，我们检查了电刺激（ES）对卵巢切除、激素启动、性接受的雌性在性活跃的雄性存在下的交配行为的影响。在13只动物中，有8只动物在间隔区设置电极，60秒的100 Hz、0.2毫秒的双相方波脉冲（80或90 μA）能有效抑制前凸反应。在最有效的情况下，即使在男性持续接触和上颌尝试期间，ES也能防止前凸。间隔区的一些神经元可能是抑制前凸表现的网络的一部分。卵巢激素促进前凸的方法之一是通过减少这种网络中的抑制活性。
The behavior of the female hamster toward the male is altered radically by estrogen and progesterone. Her aggression gives way to sexual receptivity, and the lordosis posture will commonly be maintained in the presence of a sexually active male for greater than 10 min at a time. The septal area is one of the limbic and hypothalamic areas which preferentially accumulate radioactive estradiol in the female hamster. In order to determine whether this region is involved in lordosis control, we examined the effects of electrical stimulation (ES) there on the copulatory behavior of ovariectomized, hormone-primed, sexually receptive females in the presence of sexually active males. Sixty second trains of 100 Hz, 0.2 msec, biphasic, square-wave pulses at either 80 or 90 μA were effective in suppressing the lordosis response in 8 of 13 animals with electrodes in the septal area. In the most effective cases ES would prevent lordosis even during persistent contacts and mount attempts by the male. Some neurons in the septal area may be part of a network acting to inhibit the display of lordosis. One of the ways ovarian hormones could facilitate lordosis is through reduction of the suppressive activity in such a network.