Sensory defects and developmental delay among children with congenital rubella syndrome.
Sensory defects and developmental delay among children with congenital rubella syndrome.
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DOI：
10.1038/srep46483
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发表时间：
2017-04-13
影响因子：
4.6
通讯作者：
Moriuchi H
中科院分区：
文献类型：
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作者：
Toizumi M;Nguyen GT;Motomura H;Nguyen TH;Pham E;Kaneko KI;Uematsu M;Nguyen HA;Dang DA;Hashizume M;Yoshida LM;Moriuchi H
本研究旨在探讨先天性风疹综合征（CRS）患儿的发育障碍伴感觉障碍的特点。在2011年越南庆和省发生大规模风疹疫情后，我们从2011年9月至2013年5月招募了41名CRS儿童。截至2013年10月，14名参与者死亡，6名无法追踪;其余21名儿童在2013年至2015年期间接受了随访。13名和7名参与者分别有听力和功能性眼科损伤。2013年和/或2015年，19名（95%）儿童在年龄和阶段问卷（ASQ）和/或丹佛II的至少一个领域不及格，疑似存在发育困难。在ASQ沟通领域（2013年n = 14）和丹佛II语言领域（2013年n = 13）中经常发现发展困难。2013年，7名（41%）参与者被怀疑患有自闭症谱系障碍（ASD），由幼儿自闭症改良清单。2015年，在解决问题（62%）和个人社交（62%）领域失败的儿童比例有所增加，13名儿童中有2名被诊断为ASD。在大多数CRS儿童中怀疑有发育障碍，包括自闭症主要与感觉功能障碍相结合。
This study investigated the features of developmental difficulties combined with sensory defects in children with congenital rubella syndrome (CRS). Following a large rubella outbreak in Khanh Hoa Province, Vietnam, in 2011, we enrolled 41 children with CRS from September 2011 through May 2013. Fourteen participants died and six became untraceable by October 2013; the remaining 21 children were followed up from 2013 to 2015. Thirteen and seven participants had hearing and functional ophthalmological impairment, respectively. Developmental difficulties were suspected in 19 (95%) children who failed in at least one area of the Ages and Stages Questionnaire (ASQ) and/or Denver II in 2013 and/or 2015. Developmental difficulties were frequently identified in the ASQ communication domain (n = 14 in 2013) and Denver II language area (n = 13 in 2013). Seven (41%) participants were suspected of having autism spectrum disorder (ASD) in 2013 by the Modified Checklist for Autism in Toddlers. In 2015, proportions of children failing the problem-solving (62%) and personal–social (62%) domains had increased and two of 13 were diagnosed with ASD by the Childhood Autism Rating Scale, Second Edition. Developmental difficulties were suspected in most children with CRS, including autism largely combined with sensory dysfunction.