Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
Nucleotide methylations in rRNA that confer resistance to ribosome-targeting antibiotics
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DOI：
10.1007/b105586
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Yoshizawa, S
中科院分区：
文献类型：
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作者：
Douthwaite, S;Fourmy, D;Yoshizawa, S
AbstractMethylation of rRNA nucleotides is an effective means of conferring resistance to antibiotics that target the bacterial ribosome. This type of resistance seems to have evolved as self-defence mechanisms in bacteria such as Streptomyces species that synthesize ribosome-targeting drugs. The self-defence mechanisms were subsequently recruited by pathogenic bacteria including streptococcal and staphylococcal species, where resistance to macrolides and related drugs is now a prevalent clinical problem. In this article, we review the methylation events in bacterial rRNA that confer resistance, and discuss how the molecular mechanisms of resistance can be explained from the recent crystal structures of antibiotics bound to the ribosome.
