Development of a multimodal mobile colposcope for real-time cervical cancer detection
Development of a multimodal mobile colposcope for real-time cervical cancer detection
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DOI：
10.1364/boe.463253
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发表时间：
2022-10-01
影响因子：
3.4
通讯作者：
Richards-Kortum, Rebecca
中科院分区：
文献类型：
--
作者：
Coole, Jackson B.;Brenes, David;Richards-Kortum, Rebecca
宫颈癌仍然是中低收入国家妇女癌症死亡的主要原因。在全球范围内，宫颈癌预防计划受到缺乏资源，基础设施和人员的阻碍。我们描述了一种多模式移动的阴道镜（MMC），旨在诊断宫颈癌前病变的床旁护理，而不需要活检。MMC集成了两种互补的成像系统：1）市售阴道镜和2）高速、高分辨率光纤显微内窥镜（HRME）。结合这两种图像模式允许，第一次，能够定位可疑的宫颈病变使用宽场成像，然后获得整个病变的共配准高分辨率图像。MMC克服了单独使用高分辨率成像的局限性;宽视野成像可用于指导高分辨率成像探头在临床可疑区域的放置，并且配准的镶嵌高分辨率图像有效地增加了高分辨率成像的视野。从巴西Barretos癌症医院接受阴道镜检查的患者中收集的代表性数据，包括22，800张高分辨率图像和9，900张阴道镜图像，说明MMC能够识别异常宫颈区域，以亚细胞分辨率对可疑区域进行成像，并区分高度和低度异型增生。(c)2022 Optica出版集团根据Optica开放获取出版协议的条款
Cervical cancer remains a leading cause of cancer death among women in low-and middle-income countries. Globally, cervical cancer prevention programs are hampered by a lack of resources, infrastructure, and personnel. We describe a multimodal mobile colposcope (MMC) designed to diagnose precancerous cervical lesions at the point-of-care without the need for biopsy. The MMC integrates two complementary imaging systems: 1) a commercially available colposcope and 2) a high speed, high-resolution, fiber-optic microendoscope (HRME). Combining these two image modalities allows, for the first time, the ability to locate suspicious cervical lesions using widefield imaging and then to obtain co-registered high-resolution images across an entire lesion. The MMC overcomes limitations of high-resolution imaging alone; widefield imaging can be used to guide the placement of the high-resolution imaging probe at clinically suspicious regions and co-registered, mosaicked high-resolution images effectively increase the field of view of high-resolution imaging. Representative data collected from patients referred for colposcopy at Barretos Cancer Hospital in Brazil, including 22,800 high resolution images and 9,900 colposcope images, illustrate the ability of the MMC to identify abnormal cervical regions, image suspicious areas with subcellular resolution, and distinguish between high-grade and low-grade dysplasia.(c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement