Synthesis and antifungal activities of amphiphilic PDMS-b-QPDMAEMA copolymers on Rhizoctonia solani
Synthesis and antifungal activities of amphiphilic PDMS-b-QPDMAEMA copolymers on Rhizoctonia solani
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两亲性PDMS-b-QPDMAEMA共聚物的合成及其对立枯丝核菌的抗真菌活性
DOI：
10.1021/acsabm.8b00545
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发表时间：
2018
影响因子：
4.7
通讯作者：
Anqiang Zhang
中科院分区：
文献类型：
--
作者：
Yaling Lin;Weiqiang Zhong;Chenyun Dong;Chang Zhang;Xixiang Feng;Anqiang Zhang
阳离子聚合物由于其结构和性质的可控性，是一种很有前途的植物病害杀菌剂。研究了疏水-亲水平衡对抗菌聚合物对水稻纹枯病病原菌(Rhizoctonia solaniKühn AG-1(IA))抑菌活性的影响。通过阴离子开环聚合和原子转移自由基聚合(ATRP)合成了一系列含季铵盐的聚二甲基硅氧烷-聚甲基丙烯酸酯嵌段共聚物(PDMS-b-QPDMAEMA，标记为SnQm，分别代表PDMS和QPDMAEMA链相对分子质量的1000倍)。季铵盐在OFR表面的吸附能力。茄子核属植物，渗透于植物体内。在静态水接触角和荧光标记的基础上对茄子核进行了研究。结果表明，适度疏水的PDMS链有助于稳定亲水性QPDMAEMA链的附着，从而帮助其渗透。茄子核属。其抗真菌特性为R。测定了茄尼的最低抑菌浓度(MIC)、最低杀菌浓度(MFC)和最低抑菌浓度(OFR)。茄子核发芽。疏水PDMS链对两亲性SnQmR的抗真菌活性有显著影响。茄子核属。这项工作突出了两亲性抗菌聚合物作为抗真菌药物在抑制植物病害方面的应用前景。
Cationic polymers are prospective fungicidal agents for inhibiting plant diseases because of the controllability of their structure and properties. This study investigates the effect of the hydrophobic–hydrophilic balance on the antifungal activities of antimicrobial polymers against phytopathogenic fungi (Rhizoctonia solaniKühn AG-1(IA)), the pathogen of rice sheath blight (RShB). A series of polydimethylsiloxane-polymethacrylate block copolymers containing quaternary ammonium salts (PDMS-b-QPDMAEMA, labeled as SnQm;nandmrepresent 1000th of the molecular weight of the PDMS and QPDMAEMA chain, respectively) were synthesized via anionic ring-opening polymerization and atom transfer radical polymerization (ATRP). The abilities of the quaternary ammonium salts to adsorb onto the surface ofR. solanisclerotia and permeate theR. solanisclerotia were investigated on the basis of static water contact angles and fluorescence labeling. The results indicated that the moderately hydrophobic PDMS chain helped stabilize the attachment of the hydrophilic QPDMAEMA chain and then help it penetrate theR. solanisclerotia. Its antifungal properties towardR. solaniwere characterized by determining its minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) and the inhibition rate ofR. solanisclerotia germination. The hydrophobic PDMS chains had a significant influence on the antifungal activities of amphiphilic SnQmagainstR. solanisclerotia. This work highlights the prospective application of amphiphilic antimicrobial polymers as antifungal agents for inhibiting plant diseases.