The genetic dynamics of disease.
The genetic dynamics of disease.
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疾病的遗传动力学。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
E. Murphy
中科院分区：
文献类型：
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作者：
E. Murphy
疾病遗传学的概念性原理被广泛讨论。疾病本质上是一个模糊的术语，它代表了生物体内部环境与环境之间的不协调。因此，它的动力学不能被简化为关于选择的天真陈述，这些陈述可能在几个不同的层次或组织上起作用，并且相互冲突地起作用。进化选择的结果来自于复杂性的优势，而遗传动力学的基本定理--突变债务最终必须全额偿还--可能是错误的，或者充其量是近似的。传统模型（孟德尔模型、加尔顿模型和阈值模型）是在识别迄今为止被完全忽视的疾病某些特征的背景下建立的。无论是发明还是传统的分析都是不够的。模型应该单独制作，以适合疾病的研究;疾病不应该被修剪以适应模型。
The notional principles of the genetics of disease are broadly discussed. Disease is an intrinsically vague term that represents the incongruity between the inner milieu of the organism and the environment. Its dynamics, then, cannot be reduced to naive statements about selection which may operate, and operate conflictingly, on several different levels or organization. Evolutionary selection results from the advantage of complexity, and the fundamental theorem of genetic dynamics - that mutational debts must eventually be paid in full-may be false or, at best approximate. The traditional models (mendelian, galtonian, and threshold) are set in a context that identifies certain features of disease that hitherto have been totally ignored. Neither invention nor traditional analysis has been adequate. Models should be made individually adequate for the study of diseases; the diseases should not be trimmed to fit the models.