N6-methyladenine functions as a potential epigenetic mark in eukaryotes
N6-methyladenine functions as a potential epigenetic mark in eukaryotes
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DOI：
10.1002/bies.201500076
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发表时间：
2015-11-01
期刊：
影响因子：
4
通讯作者：
Chen, Dahua
中科院分区：
文献类型：
--
作者：
Sun, Qinmiao;Huang, Shoujun;Chen, Dahua
N-6-甲基腺嘌呤（6 mA）是最丰富的DNA甲基化类型之一，在细菌中起着重要的作用;然而，它在高等真核生物，如植物，昆虫和哺乳动物中的作用被认为不太重要。最近的研究强调6 mA确实存在，并且它在真核生物中起着重要作用，例如蠕虫、苍蝇和绿色藻类，因此6 mA的调节已经成为高等真核生物中一种新的表观遗传机制。尽管这一有趣的发展，一些重要的问题，其生物学作用尚未得到解决。在这篇综述中，我们专注于5 mC和6 mA的修改，在其生产，分布，并在高等真核生物，包括哺乳动物的擦除6 mA。我们对6 mA的潜在功能进行了分析，从而拓宽了对高等真核生物中这种新的表观遗传标记的理解，并提出了该领域未来的研究方向。
N-6-methyladenine (6mA) is one of the most abundant types of DNA methylation, and plays an important role in bacteria; however, its roles in higher eukaryotes, such as plants, insects, and mammals, have been considered less important. Recent studies highlight that 6mA does indeed occur, and that it plays an important role in eukaryotes, such as worm, fly, and green algae, and thus the regulation of 6mA has emerged as a novel epigenetic mechanism in higher eukaryotes. Despite this intriguing development, a number of important issues regarding its biological roles are yet to be addressed. In this review, we focus on the 5mC and 6mA modifications in terms of their production, distribution, and the erasure of 6mA in higher eukaryotes including mammals. We perform an analysis of the potential functions of 6mA, hence widening understanding of this new epigenetic mark in higher eukaryotes, and suggesting future studies in this field.