Local anisotropic mechanical properties of human carotid atherosclerotic plaques - Characterisation by micro-indentation and inverse finite element analysis
Local anisotropic mechanical properties of human carotid atherosclerotic plaques - Characterisation by micro-indentation and inverse finite element analysis
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DOI：
10.1016/j.jmbbm.2014.12.004
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发表时间：
2015-03-01
影响因子：
3.9
通讯作者：
Baaijens, Frank P. T.
中科院分区：
文献类型：
--
作者：
Chai, Chen-Ket;Akyildiz, Ali C.;Baaijens, Frank P. T.
生物力学模型有可能预测动脉粥样硬化斑块的失败，并改善斑块破裂的风险评估。这些模型的适用性在很大程度上取决于所使用的材料模型。目前的生物力学模型采用各向同性材料模型，尽管普遍认为斑块组织表现出高度各向异性。本研究的目的是确定局部各向异性力学性能的人类动脉粥样硬化斑块组织的微压痕试验。在倒置共聚焦显微镜的顶部进行压痕，允许垂直于斑块压痕方向的胶原纤维变形的可视化和定量。在此基础上，推导出垂直于压痕方向的斑块组织（纤维帽中部、帽肩部、剩余内膜组织）的各向异性特性。不同压痕位置之间的纤维硬度（总中位数80.6 kPa，第25 - 75百分位数17.7-157.0 kPa）和纤维分散度无显著差异。(C)2014爱思唯尔有限公司版权所有。
Biomechanical models have the potential to predict failure of atherosclerotic plaques and to improve the risk assessment of plaque rupture. The applicability of these models depends strongly on the used material models. Current biomechanical models employ isotropic material models, although it is generally accepted that plaque tissue behaves highly anisotropic. The aim of the present study is to determine the local anisotropic mechanical properties of human atherosclerotic plaque tissue by means of micro-indentation tests. The indentation was performed on top of an inverted confocal microscope allowing the visualisation and quantification of the collagen fibre deformations perpendicular to the indentation direction of the plaque. Based on this, the anisotropic properties of plaque tissue perpendicular to the indentation direction (middle of the fibrous cap, shoulder of the cap, remaining intima tissue) were derived. There were no significant differences between the different indentation locations for the fibre stiffness (total median 80.6 kPa, 25th-75th percentile 17.7-157.0 kPa), and fibre dispersion. (C) 2014 Elsevier Ltd. All rights reserved.