The carcinogenic effect of UVA irradiation.
The carcinogenic effect of UVA irradiation.
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UVA照射的致癌作用。
DOI：
10.1111/1523-1747.ep12522855
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
H. Brodthagen
中科院分区：
文献类型：
--
作者：
B. Staberg;H. Wulf;P. Klemp;T. Poulsen;H. Brodthagen
在7组25只浅色无毛小鼠中研究了UVA辐射（来自飞利浦黑光管，通过2 mm厚的玻璃板过滤，以消除320 nm以下的辐射）的致癌作用。用中等剂量的UVB和UVA联合照射3个月，58周后肿瘤发生率为0.22。当UVB和UVA联合照射2、4或6个月后再进行滤过UVA照射时，肿瘤发生率分别略微显著增加至0.42、0.48和0.50（p <0.05）。然而，与单独的UVB相比，用中等剂量的UVB和UVA组合照射诱导轻微但不显著的肿瘤发生率降低（0.22 vs 0.30，p大于0.1）。UVA单独不诱导肿瘤。因此，在最初暴露于UVB和UVA组合的无毛小鼠中，随后用UVA继续照射增加了肿瘤发病率。虽然只有轻微的统计学显著性，但这些动物中的肿瘤发生率似乎随着持续时间和总UVA暴露而增加。此外，有人建议，从未过滤的UVA灯泡的UVA照射的光增强致癌作用可以通过衰减较短波长的辐射来减少。
The carcinogenic effect of UVA radiation (from Philips black light tubes filtered through a 2 mm-thick glass plate to eliminate the radiation below 320 nm) was studied in 7 groups of 25 lightly pigmented hairless mice. Irradiation with a moderate daily dose of combined UVB and UVA for 3 months induced a tumor incidence of 0.22 after 58 weeks. When the combined UVB and UVA irradiation was followed by filtered UVA for 2, 4, or 6 months, the tumor incidence was marginally significantly increased to 0.42, 0.48, and 0.50 (p less than 0.05), respectively. However, irradiation with the moderate dose of combined UVB and UVA induced a slight but not significantly lower tumor incidence as compared to UVB alone (0.22 vs 0.30, p greater than 0.1). UVA alone induced no tumors. It thus appears that in hairless mice initially exposed to a combination of UVB and UVA, subsequent continued irradiation with UVA increases tumor incidence. While only marginally statistically significant, tumor incidence in these animals seems to increase with duration and hence total UVA exposure. Furthermore, it is suggested that the photoaugmentative carcinogenic effect of UVA irradiation from unfiltered UVA bulbs can be reduced by attenuating the shorter wavelengths of the radiation.