Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness
Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness
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DOI：
10.1093/sleep/zsz033
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发表时间：
2019-05-01
期刊：
影响因子：
5.6
通讯作者：
Bagshaw, Andrew P.
中科院分区：
文献类型：
--
作者：
Facer-Childs, Elise R.;Campos, Brunno M.;Bagshaw, Andrew P.
简介人脑内在连接网络的功能连接(FC)是认知功能的基础，FC的中断与睡眠和神经功能障碍有关。然而，关于昼夜节律表型和时间对Fc的影响的研究有限。研究目的本研究的目的是研究在社会受限的一天内，早期和晚期昼夜节律表型的默认模式网络(DMN)的静息状态FC。方法38名健康个体(14名男性，22.7岁，4.2岁)采用慕尼黑时型问卷，分为早(n=16)和晚(n=22)两组。在为期两周的活动描记基线加上唾液样本的褪黑素和皮质醇节律之后，参与者在第二天早上14：00、20：00和08：00进行了测试。测试包括静息状态功能磁共振成像(FMRI)、结构性T1扫描、注意力认知表现任务和自我报告的日间嗜睡。对DMN的前额内侧和后扣带回皮质进行基于种子的FC分析，并进行组间比较，并与行为数据相结合。结果在早期和晚期的昼夜节律表型中，DMN有根本的差异。DMN的静息状态FC预测了个体注意力和嗜睡的主观评级的差异。结论DMN的FC差异可能是迟发性患者在符合与其固有的昼夜表型不匹配的社会约束的一天时，注意力表现受损和嗜睡增加的基础。
Introduction Functional connectivity (FC) of the human brain's intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study Objectives The aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.Methods Thirty-eight healthy individuals (14 male, 22.7 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.Results Fundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.Conclusion Differences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.