The aging baboon: Comparative demography in a non-human primate
The aging baboon: Comparative demography in a non-human primate
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DOI：
10.1073/pnas.142675599
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发表时间：
2002-07-09
影响因子：
11.1
通讯作者：
Tatar, M
中科院分区：
文献类型：
--
作者：
Bronikowski, AM;Alberts, SC;Tatar, M
为什么亲缘关系密切的灵长类动物的寿命会有所不同，这对人类衰老有什么启示？东非两个野生种群和德克萨斯州圣安东尼奥大量圈养种群的雌性狒狒（Papio hamadryas）的生命表与人类死亡模式有着惊人的相似和对比。对于西南生物医学研究基金会的圈养狒狒，我们估计成年死亡率翻倍的时间为4.8年。在坦桑尼亚和肯尼亚的自由生活种群中，野生雌性的寿命分别为3.5岁和3.8岁，翻了一番。虽然这些数值比人类估计的7-8年要快得多，但这些灵长类动物具有人类衰老的人口统计学特征：在每个分类单元中，种群主要在Gompertz死亡率截距（脆弱）水平上变化，而人口老龄化率变化不大。分类群内的环境和遗传因素似乎会影响衰老背后的脆弱程度。相比之下，灵长类类群是通过人口老龄化率来区分的，即使它们不能以物种特定的寿命来表征。
Why do closely related primate genera vary in longevity, and what does this teach us about human aging? Life tables of female baboons (Papio hamadryas) in two wild populations of East Africa and in a large captive population in San Antonio, Texas, provide striking similarities and contrasts to human mortality patterns. For captive baboons at the Southwest Foundation for Biomedical Research, we estimate the doubling time of adult mortality rate as 4.8 years. Wild females in free-living populations in Tanzania and In Kenya showed doubling times of 3.5 and 3.8 years, respectively. Although these values are considerably faster than the estimates of 7-8 years for humans, these primates share a demographic feature of human aging: within each taxon populations primarily vary in the level of Gompertz mortality intercept (frailty) and vary little in the demographic rate of aging. Environmental and genetic factors within taxa appear to affect the level of frailty underlying senescence. In contrast, primate taxa are differentiated by rates of demographic aging, even if they cannot be characterized by species-specific lifespan.