Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials.
Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials.
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DOI：
10.1210/edrv-17-5-533
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发表时间：
1996-10
影响因子：
20.3
通讯作者：
S. Wimalawansa
中科院分区：
文献类型：
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作者：
S. Wimalawansa
降钙素(CT)和降钙素基因相关肽(CGRP)是由CT/CGRP基因衍生而来的，位于第11号染色体上。初级RNA转录本的选择性剪接导致CGRP和CT肽以组织特异性的方式翻译。这种来自大鼠α-CT/CGRP基因的初级组织特异性处理产生了两种截然不同的多肽：CT和CGRP(1，2)。CGRP是一种由37个氨基酸组成的神经肽，主要在神经系统表达，CT主要在甲状腺表达。降钙素基因相关肽受体广泛分布于体内，是已发现的最有效的内源性血管扩张肽。CT来源于甲状腺的C细胞，是破骨细胞介导的骨吸收的最有效的多肽抑制物，主要参与在生长、怀孕和哺乳期的“钙压力”期间保护骨骼(3)。1961年，科普和他的同事(4)假设了钙离子的存在。
I. Introduction THE calcitonin (CT) and calcitonin gene-related peptide (CGRP) are derived from the CT/CGRP gene, which is localized in chromosome 11. Alternative splicing of the primary RNA transcript leads to the translation of CGRP and CT peptides in a tissue-specific manner. This alternative tissue-specific processing of primary mRNA from the α-CT/CGRP gene in rats generates two distinct peptides, CT and CGRP (1, 2). CGRP is a 37-amino acid neuropeptide expressed predominantly in the nervous system and CT is expressed mainly in the thyroid gland. CGRP receptors, widely distributed in the body, are the most potent endogenous vasodilatory peptides that have been discovered. Derived from the C cells of the thyroid gland, CT is the most potent peptide inhibitor of osteoclast-mediated bone resorption and is involved primarily in protecting the skeleton during periods of “calcium stress” such as growth, pregnancy, and lactation (3). In 1961, Copp and colleagues (4) postulated the existence of the calcium-lo...